Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3002015..3002651 Replicon chromosome
Accession NZ_CP049742
Organism Mangrovibacillus cuniculi strain R1DC41

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G8O30_RS15255 Protein ID WP_239674578.1
Coordinates 3002301..3002651 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G8O30_RS15250 Protein ID WP_239672872.1
Coordinates 3002015..3002296 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8O30_RS15220 (G8O30_15205) 2997394..2998107 + 714 WP_239672866.1 SDR family oxidoreductase -
G8O30_RS15225 (G8O30_15210) 2998121..2998270 - 150 WP_239672867.1 hypothetical protein -
G8O30_RS15230 (G8O30_15215) 2998327..2998929 - 603 WP_239672868.1 rhomboid family intramembrane serine protease -
G8O30_RS15235 (G8O30_15220) 2998975..2999364 + 390 WP_239672869.1 holo-ACP synthase -
G8O30_RS15240 (G8O30_15225) 2999644..3000660 + 1017 WP_239672870.1 outer membrane lipoprotein carrier protein LolA -
G8O30_RS15245 (G8O30_15230) 3000720..3001883 + 1164 WP_239672871.1 alanine racemase -
G8O30_RS15250 (G8O30_15235) 3002015..3002296 + 282 WP_239672872.1 antitoxin endoai Antitoxin
G8O30_RS15255 (G8O30_15240) 3002301..3002651 + 351 WP_239674578.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G8O30_RS15260 (G8O30_15245) 3002661..3003512 - 852 WP_239672873.1 hypothetical protein -
G8O30_RS15265 (G8O30_15250) 3003653..3004471 + 819 WP_239672874.1 STAS domain-containing protein -
G8O30_RS15270 (G8O30_15255) 3004468..3004824 + 357 WP_239672875.1 STAS domain-containing protein -
G8O30_RS15275 (G8O30_15260) 3004829..3005230 + 402 WP_239672876.1 anti-sigma regulatory factor -
G8O30_RS15280 (G8O30_15265) 3005242..3006246 + 1005 WP_239672877.1 PP2C family protein-serine/threonine phosphatase -
G8O30_RS15285 (G8O30_15270) 3006310..3006639 + 330 WP_239672878.1 anti-sigma factor antagonist -
G8O30_RS15290 (G8O30_15275) 3006636..3007112 + 477 WP_239672879.1 anti-sigma B factor RsbW -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13123.20 Da        Isoelectric Point: 5.1961

>T151515 WP_239674578.1 NZ_CP049742:3002301-3002651 [Mangrovibacillus cuniculi]
MMVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYKFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMERVDEALQISVGLIEF

Download         Length: 351 bp

>T151515 NZ_CP065603:c106005-105511 [Burkholderia glumae]
ATGACGGGCTGGCTCGCGCCCGAACCGCTCGGCGACGCGCATGGACTCGACGATTTCGATTCCGGCGTCGCGAGCCTCGA
CACGTGGCTCAAACGTCGTGCATTTGCCAATCAGCGAAGCGGTGCGTCGCGGACCTTTGTGGCGACGCGAGACGGTCGGG
TGGGGGCGTACTACGCACTCGCGTCCGGCGCGGTTACGCTCGAGGTCGCACCGGGCCGCTTCCGACGCAACATGCCCGAT
CCGATACCCGTGGTTGTGCTCGGGCGTCTAGCCGTCGATCGCGCCCATCAGGGCAATGGAGTTGGGCGTGCGCTGGTACG
CGATGTCGGTTTGCGTGTACTGCACGCCGCAGCGGCCATCGGAATTCGCGGCCTGATTGTCCATGCGCTCACGGATTCGG
CCAAGGCGTTTTACGAGCGGGTGGGCTTTGAGGCGTCGCCAATCGATCCGATGCTGCTCCTGATCACGCTGGCCGACCTT
GAACACGCCTTATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10773.22 Da        Isoelectric Point: 5.7711

>AT151515 WP_239672872.1 NZ_CP049742:3002015-3002296 [Mangrovibacillus cuniculi]
VSESSAKTEVLIQLPQHFLAELDGFAEQENVNRSEFIYRAAKVYLRERKKRQIRETMRRGYMEMAKINLEIASEALQAEF
EAEHTVERLVSGG

Download         Length: 282 bp

>AT151515 NZ_CP065603:c106283-106002 [Burkholderia glumae]
ATGACCTCGACCACCCCACGCGACACCCTGAACCTACGCATTCGTCCTGACGATCGCAGCTTGATTGACCGCGCCGCAGC
GGCCGCCCACAAAACGCGTACCGACTTCGTCTTGGACGCAGCGCGGGCCGCCGCCGAACAGACCTTGCTCGACCAGGTTG
TTCTGAGCGCTGAGCCGCAGGCCTACGCGGCCTTCCTGGCGCGCCTGGATGCGCCCGCCCAACCGAATGCGGCATTGCGT
CAGACCATGCAGACGCGCGCGCCCTGGGACCCCGCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References