151509

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4359269..4359857 Replicon chromosome
Accession NZ_CP049739
Organism Citrobacter sp. SX212

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag G8S20_RS21110 Protein ID WP_124021092.1
Coordinates 4359269..4359586 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag G8S20_RS21115 Protein ID WP_124021093.1
Coordinates 4359579..4359857 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8S20_RS21075 (4354758) 4354758..4355051 - 294 WP_124021088.1 type II toxin-antitoxin system CcdA family antitoxin -
G8S20_RS21080 (4355147) 4355147..4355512 - 366 WP_124021089.1 hypothetical protein -
G8S20_RS21085 (4355644) 4355644..4355817 + 174 WP_032938222.1 hypothetical protein -
G8S20_RS21090 (4355888) 4355888..4356049 + 162 WP_005132808.1 hypothetical protein -
G8S20_RS21095 (4356196) 4356196..4356702 - 507 WP_124021090.1 HNH endonuclease -
G8S20_RS21100 (4356917) 4356917..4357657 - 741 WP_124021091.1 DUF2971 domain-containing protein -
G8S20_RS21105 (4357871) 4357871..4359031 - 1161 WP_253685221.1 IS30 family transposase -
G8S20_RS21110 (4359269) 4359269..4359586 + 318 WP_124021092.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G8S20_RS21115 (4359579) 4359579..4359857 + 279 WP_124021093.1 putative addiction module antidote protein Antitoxin
G8S20_RS21120 (4359967) 4359967..4360656 + 690 WP_032942056.1 dipeptidase PepE -
G8S20_RS21125 (4360718) 4360718..4362349 - 1632 WP_124021094.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4357871..4359031 1160


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(3-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11997.89 Da        Isoelectric Point: 10.1424

>T151509 WP_124021092.1 NZ_CP049739:4359269-4359586 [Citrobacter sp. SX212]
IMEILQTTVFQRWEQNLRDRRAKTLIAARLFRLANGLAGDVKPVGEGISEMRISYGPGYRIYFKQHGCRIIILLCGGDKS
SQANNITLAKVLARSLDYQETFRHE

Download         Length: 318 bp

>T151509 NZ_CP065582:208397-208693 [Mycoplasma mycoides subsp. capri]
ATGACTAAATATAAAATTGTTTGAACAACAAAATTTAAAAAGGATTTAAAGCTAGCTAAAAAACAGAATAAAGATTTAAA
TAAACTAGACTATGTTATTAATATATTAACTCAAGGCAAAGAGTTAGACGCAAAATATCAAGATCATTCACTTACTGGCA
TTTATAAAGGATATAGAGAGTGCCATATTGACCCTGACTGACTTTTAATATATAAAAAAGATGATGATAAAATTGTTATA
ACAATGTTAAGATTAGGTTCACATTCTAATTTATTTGAAAAACAAAAAAACTACTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9791.33 Da        Isoelectric Point: 6.2976

>AT151509 WP_124021093.1 NZ_CP049739:4359579-4359857 [Citrobacter sp. SX212]
MNKLTQYDPAAALVDDEEIAVFMADALETGDATYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKALGIGLTLRK

Download         Length: 279 bp

>AT151509 NZ_CP065582:208132-208404 [Mycoplasma mycoides subsp. capri]
ATGAAAACAACAAATTTAAACGTAAGAATTGATAAAGAAGTCAAACATGATGCAGAAGCTATATTTAATGAATTGGGTTT
AAGCACATCAGCAGCTATAAATATGTTTTTTAAAGCTACAATTAGAAATAACAGTCTTCCTTTTAGCACTAAACTGGATA
CTCCTAATAAAGAAACTTTGTTAGCTATGAAAGAAGCAGAAGAACTATTAAAAGATCCAAATACAAAGTATTATTCAAGC
TTTAAAGAACTTTTAGAGACATTAGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References