Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3693776..3694530 | Replicon | chromosome |
| Accession | NZ_CP049739 | ||
| Organism | Citrobacter sp. SX212 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A6I5AL91 |
| Locus tag | G8S20_RS18030 | Protein ID | WP_023567999.1 |
| Coordinates | 3694153..3694530 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | G8S20_RS18025 | Protein ID | WP_074143921.1 |
| Coordinates | 3693776..3694102 (+) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G8S20_RS17980 (3689094) | 3689094..3689807 | + | 714 | WP_023567990.1 | sporulation transcriptional regulator SpoIIID | - |
| G8S20_RS17985 (3689809) | 3689809..3689958 | + | 150 | WP_001458941.1 | hypothetical protein | - |
| G8S20_RS17990 (3689970) | 3689970..3690185 | + | 216 | WP_023567991.1 | hypothetical protein | - |
| G8S20_RS17995 (3690235) | 3690235..3691182 | + | 948 | WP_023567992.1 | Ivy family c-type lysozyme inhibitor | - |
| G8S20_RS18000 (3691270) | 3691270..3691503 | + | 234 | WP_023567993.1 | DUF905 domain-containing protein | - |
| G8S20_RS18005 (3691614) | 3691614..3692435 | + | 822 | WP_023567994.1 | DUF932 domain-containing protein | - |
| G8S20_RS18010 (3692516) | 3692516..3692986 | + | 471 | WP_023567995.1 | antirestriction protein | - |
| G8S20_RS18015 (3692998) | 3692998..3693477 | + | 480 | WP_023567996.1 | DNA repair protein RadC | - |
| G8S20_RS18020 (3693498) | 3693498..3693719 | + | 222 | WP_023567997.1 | DUF987 domain-containing protein | - |
| G8S20_RS18025 (3693776) | 3693776..3694102 | + | 327 | WP_074143921.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| G8S20_RS18030 (3694153) | 3694153..3694530 | + | 378 | WP_023567999.1 | TA system toxin CbtA family protein | Toxin |
| G8S20_RS18035 (3694527) | 3694527..3695018 | + | 492 | WP_023568000.1 | DUF5983 family protein | - |
| G8S20_RS18040 (3695045) | 3695045..3695248 | + | 204 | WP_023568001.1 | DUF957 domain-containing protein | - |
| G8S20_RS18045 (3695330) | 3695330..3696175 | + | 846 | Protein_3534 | DUF4942 domain-containing protein | - |
| G8S20_RS18055 (3696518) | 3696518..3696826 | - | 309 | WP_232034718.1 | isoprenylcysteine carboxylmethyltransferase family protein | - |
| G8S20_RS18060 (3697175) | 3697175..3698623 | - | 1449 | WP_116360953.1 | EAL domain-containing protein | - |
| G8S20_RS18065 (3698965) | 3698965..3699438 | - | 474 | WP_121584245.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14063.88 Da Isoelectric Point: 6.7110
>T151507 WP_023567999.1 NZ_CP049739:3694153-3694530 [Citrobacter sp. SX212]
MQTQPLSSTQEATPRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKCDLVRTDRRGL
NAETQSPLLSSIDILRARKATGLMTRNDYKVVTDITNGKYREGQR
MQTQPLSSTQEATPRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKCDLVRTDRRGL
NAETQSPLLSSIDILRARKATGLMTRNDYKVVTDITNGKYREGQR
Download Length: 378 bp
>T151507 NZ_CP065576:963155-963433 [Mycoplasma mycoides subsp. capri]
ATGATTAAGTACACAATACTTACTACAACAAAATTTATTAAAGATTTGAAGTTAGCTAAAAAACAAAATAAAAATTTAGA
AAAACTTGACATAATTATTAATAAGTTAGAAAATGATGAAATATTAGACAAAAAATATAAAGATCATCCACTCACTGGTA
AATATGAAGGTTATAGAGAATGTCATATAGAGCCTGATTGACTTTTAATTTATAAAAAGGAGAAAAAAGATCTTCTTTTA
GTACTTTTTAGGTTGGGTTCTCACTCTAAAATACTCTAA
ATGATTAAGTACACAATACTTACTACAACAAAATTTATTAAAGATTTGAAGTTAGCTAAAAAACAAAATAAAAATTTAGA
AAAACTTGACATAATTATTAATAAGTTAGAAAATGATGAAATATTAGACAAAAAATATAAAGATCATCCACTCACTGGTA
AATATGAAGGTTATAGAGAATGTCATATAGAGCCTGATTGACTTTTAATTTATAAAAAGGAGAAAAAAGATCTTCTTTTA
GTACTTTTTAGGTTGGGTTCTCACTCTAAAATACTCTAA
Antitoxin
Download Length: 109 a.a. Molecular weight: 11953.71 Da Isoelectric Point: 6.8397
>AT151507 WP_074143921.1 NZ_CP049739:3693776-3694102 [Citrobacter sp. SX212]
ITEPWWGLKRSITPCFGARLVQAGNRLHYLADRANITGQFSDADLRYLDQAFPLLLKQLELMLTSGELNPCHQHCVTLYA
KGLTCEADSLGSHGYVYLAIYPTPAATA
ITEPWWGLKRSITPCFGARLVQAGNRLHYLADRANITGQFSDADLRYLDQAFPLLLKQLELMLTSGELNPCHQHCVTLYA
KGLTCEADSLGSHGYVYLAIYPTPAATA
Download Length: 327 bp
>AT151507 NZ_CP065576:962890-963162 [Mycoplasma mycoides subsp. capri]
GTGAAAACAACAAATGTAAATATTAAGATGGATCCTGAAATTAAAAAACAGGCTAGTTTACTATTTAAAGAATTTGGCAT
GACCATGTCTTCTGCTATTAACCTATTTGTGAAAACTGCTGTTGAACAAAACGACATTCCATTTGAATATAATAGAGAGA
TAACTAACAAAGAAACTCTAGAAGCTTTTGAAGAAGGTGAACGTCTTTTAGCTGATAAAAACGCAAAACGTTACTCAAGT
TTTAAAGAAATATTAGACTCGTTAGATGATTAA
GTGAAAACAACAAATGTAAATATTAAGATGGATCCTGAAATTAAAAAACAGGCTAGTTTACTATTTAAAGAATTTGGCAT
GACCATGTCTTCTGCTATTAACCTATTTGTGAAAACTGCTGTTGAACAAAACGACATTCCATTTGAATATAATAGAGAGA
TAACTAACAAAGAAACTCTAGAAGCTTTTGAAGAAGGTGAACGTCTTTTAGCTGATAAAAACGCAAAACGTTACTCAAGT
TTTAAAGAAATATTAGACTCGTTAGATGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|