151506

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3472969..3473589 Replicon chromosome
Accession NZ_CP049739
Organism Citrobacter sp. SX212

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag G8S20_RS16965 Protein ID WP_002892050.1
Coordinates 3473371..3473589 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag G8S20_RS16960 Protein ID WP_003021733.1
Coordinates 3472969..3473343 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8S20_RS16950 (3468115) 3468115..3469308 + 1194 WP_048212410.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G8S20_RS16955 (3469331) 3469331..3472480 + 3150 WP_048212411.1 efflux RND transporter permease AcrB -
G8S20_RS16960 (3472969) 3472969..3473343 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
G8S20_RS16965 (3473371) 3473371..3473589 + 219 WP_002892050.1 HHA domain-containing protein Toxin
G8S20_RS16970 (3473778) 3473778..3474329 + 552 WP_061067437.1 maltose O-acetyltransferase -
G8S20_RS16975 (3474446) 3474446..3474916 + 471 WP_040232692.1 YlaC family protein -
G8S20_RS16980 (3474994) 3474994..3475134 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
G8S20_RS16985 (3475136) 3475136..3475396 - 261 WP_005125189.1 type B 50S ribosomal protein L31 -
G8S20_RS16990 (3475585) 3475585..3477138 + 1554 WP_253685568.1 EAL domain-containing protein -
G8S20_RS16995 (3477193) 3477193..3477546 - 354 WP_061067436.1 DUF1428 family protein -
G8S20_RS17000 (3477629) 3477629..3478240 - 612 WP_121584303.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T151506 WP_002892050.1 NZ_CP049739:3473371-3473589 [Citrobacter sp. SX212]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T151506 NZ_CP065575:977533-977811 [Mycoplasma mycoides subsp. capri]
ATGATTAAGTACACAATACTTACTACAACAAAATTTATTAAAGATTTGAAGTTAGCTAAAAAACAAAATAAAAATTTAGA
AAAACTTGACATAATTATTAATAAGTTAGAAAATGATGAAATATTAGACAAAAAATATAAAGATCATCCACTCACTGGTA
AATATGAAGGTTATAGAGAATGTCATATAGAGCCTGATTGACTTTTAATTTATAAAAAGGAGAAAAAAGATCTTCTTTTA
GTACTTTTTAGGTTGGGTTCTCACTCTAAAATACTCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT151506 WP_003021733.1 NZ_CP049739:3472969-3473343 [Citrobacter sp. SX212]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT151506 NZ_CP065575:977268-977540 [Mycoplasma mycoides subsp. capri]
GTGAAAACAACAAATGTAAATATTAAGATGGATCCTGAAATTAAAAAACAGGCTAGTTTACTATTTAAAGAATTTGGCAT
GACCATGTCTTCTGCTATTAACCTATTTGTGAAAACTGCTGTTGAACAAAACGACATTCCATTTGAATATAATAGAGAGA
TAACTAACAAAGAAACTCTAGAAGCTTTTGAAGAAGGTGAACGTCTTTTAGCTGATAAAAACGCAAAACGTTACTCAAGT
TTTAAAGAAATATTAGACTCGTTAGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References