Detailed information of TA system TA151497

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 799373..800027
• Replicon: chromosome
• Accession: NZ_CP049739
• Organism: Citrobacter sp. SX212

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: G8S20_RS03910
• Protein ID: WP_048213165.1
• Coordinates: 799620..800027 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A6N6K0R3
• Locus tag: G8S20_RS03905
• Protein ID: WP_005123351.1
• Coordinates: 799373..799639 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G8S20_RS03880 (794574)	794574..796007	-	1434	WP_253686110.1	6-phospho-beta-glucosidase BglA	-
G8S20_RS03885 (796128)	796128..796856	-	729	WP_061068520.1	MurR/RpiR family transcriptional regulator	-
G8S20_RS03890 (796909)	796909..797220	+	312	WP_048213167.1	N(4)-acetylcytidine aminohydrolase	-
G8S20_RS03895 (797384)	797384..798043	+	660	WP_101742747.1	hemolysin III family protein	-
G8S20_RS03900 (798137)	798137..799117	-	981	WP_137364342.1	tRNA-modifying protein YgfZ	-
G8S20_RS03905 (799373)	799373..799639	+	267	WP_005123351.1	FAD assembly factor SdhE	Antitoxin
G8S20_RS03910 (799620)	799620..800027	+	408	WP_048213165.1	protein YgfX	Toxin
G8S20_RS03915 (800119)	800119..800640	-	522	WP_048213164.1	flavodoxin FldB	-
G8S20_RS03920 (800754)	800754..801650	+	897	WP_253686112.1	site-specific tyrosine recombinase XerD	-
G8S20_RS03925 (801674)	801674..802387	+	714	WP_101742745.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
G8S20_RS03930 (802393)	802393..804126	+	1734	WP_115601508.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15940.86 Da
• Isoelectric Point: 10.9468

>T151497 WP_048213165.1 NZ_CP049739:799620-800027 [Citrobacter sp. SX212]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVCAPWMIKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQQVKQG

Nucleotide

• Length: 408 bp

>T151497 NZ_CP065554:c4817527-4816994 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10642.16 Da
• Isoelectric Point: 5.1700

>AT151497 WP_005123351.1 NZ_CP049739:799373-799639 [Citrobacter sp. SX212]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDNLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADEQLEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT151497 NZ_CP065554:c4817804-4817538 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A6N6K0R3