Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4475118..4475734 Replicon chromosome
Accession NZ_CP049738
Organism Citrobacter sp. SX206

Toxin (Protein)


Gene name vapC Uniprot ID A0A0J1MQ96
Locus tag G8S19_RS21560 Protein ID WP_003028682.1
Coordinates 4475118..4475492 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6B5NTK4
Locus tag G8S19_RS21565 Protein ID WP_043018956.1
Coordinates 4475492..4475734 (-) Length 81 a.a.

Genomic Context

G8S19_RS21545G8S19_RS21550G8S19_RS21555G8S19_RS21570G8S19_RS21575G8S19_RS21580G8S19_RS21560G8S19_RS21565G8S19_RS21585G8S19_RS21590G8S19_RS21595G8S19_RS21600
Location: 4472621..4473523 (903 bp)
Type: Others
Protein ID: WP_003028691.1
Location: 4473520..4474155 (636 bp)
Type: Others
Protein ID: WP_137381433.1
Location: 4474152..4475081 (930 bp)
Type: Others
Protein ID: WP_003028685.1
Location: 4475939..4476868 (930 bp)
Type: Others
Protein ID: WP_253685870.1
Location: 4476954..4477265 (312 bp)
Type: Others
Protein ID: WP_115601211.1
Location: 4477262..4477708 (447 bp)
Type: Others
Protein ID: WP_253685871.1
Location: 4475118..4475492 (375 bp)
Type: Toxin
Protein ID: WP_003028682.1
Location: 4475492..4475734 (243 bp)
Type: Antitoxin
Protein ID: WP_043018956.1
Location: 4477720..4478661 (942 bp)
Type: Others
Protein ID: WP_048214031.1
Location: 4478706..4479143 (438 bp)
Type: Others
Protein ID: WP_003028671.1
Location: 4479140..4480012 (873 bp)
Type: Others
Protein ID: WP_121585273.1
Location: 4480006..4480605 (600 bp)
Type: Others
Protein ID: WP_048214033.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
G8S19_RS21545 (4472621)4472621..4473523+903WP_003028691.1formate dehydrogenase O subunit beta-
G8S19_RS21550 (4473520)4473520..4474155+636WP_137381433.1formate dehydrogenase cytochrome b556 subunit-
G8S19_RS21555 (4474152)4474152..4475081+930WP_003028685.1formate dehydrogenase accessory protein FdhE-
G8S19_RS21560 (4475118)4475118..4475492-375WP_003028682.1type II toxin-antitoxin system VapC family toxinToxin
G8S19_RS21565 (4475492)4475492..4475734-243WP_043018956.1CopG family transcriptional regulatorAntitoxin
G8S19_RS21570 (4475939)4475939..4476868+930WP_253685870.1alpha/beta hydrolase-
G8S19_RS21575 (4476954)4476954..4477265+312WP_115601211.1type II toxin-antitoxin system HigB family toxin-
G8S19_RS21580 (4477262)4477262..4477708+447WP_253685871.1helix-turn-helix domain-containing protein-
G8S19_RS21585 (4477720)4477720..4478661-942WP_048214031.1fatty acid biosynthesis protein FabY-
G8S19_RS21590 (4478706)4478706..4479143-438WP_003028671.1D-aminoacyl-tRNA deacylase-
G8S19_RS21595 (4479140)4479140..4480012-873WP_121585273.1virulence factor BrkB family protein-
G8S19_RS21600 (4480006)4480006..4480605-600WP_048214033.1glucose-1-phosphatase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13674.89 Da        Isoelectric Point: 9.5622

>T151495 WP_003028682.1 NZ_CP049738:c4475492-4475118 [Citrobacter sp. SX206]
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL

Download         Length: 375 bp

>T151495 NZ_CP065554:c2743997-2742675 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9451.75 Da        Isoelectric Point: 4.3437

>AT151495 WP_043018956.1 NZ_CP049738:c4475734-4475492 [Citrobacter sp. SX206]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp

>AT151495 NZ_CP065554:c2744263-2743997 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0J1MQ96

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A6B5NTK4

References