Detailed information of TA system TA151494

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 4328467..4329055
• Replicon: chromosome
• Accession: NZ_CP049738
• Organism: Citrobacter sp. SX206

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: G8S19_RS20895
• Protein ID: WP_124021092.1
• Coordinates: 4328467..4328784 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: G8S19_RS20900
• Protein ID: WP_124021093.1
• Coordinates: 4328777..4329055 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G8S19_RS20860 (4323956)	4323956..4324249	-	294	WP_124021088.1	type II toxin-antitoxin system CcdA family antitoxin	-
G8S19_RS20865 (4324345)	4324345..4324710	-	366	WP_124021089.1	hypothetical protein	-
G8S19_RS20870 (4324842)	4324842..4325015	+	174	WP_032938222.1	hypothetical protein	-
G8S19_RS20875 (4325086)	4325086..4325247	+	162	WP_005132808.1	hypothetical protein	-
G8S19_RS20880 (4325394)	4325394..4325900	-	507	WP_124021090.1	HNH endonuclease	-
G8S19_RS20885 (4326115)	4326115..4326855	-	741	WP_124021091.1	DUF2971 domain-containing protein	-
G8S19_RS20890 (4327069)	4327069..4328229	-	1161	WP_253685221.1	IS30 family transposase	-
G8S19_RS20895 (4328467)	4328467..4328784	+	318	WP_124021092.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G8S19_RS20900 (4328777)	4328777..4329055	+	279	WP_124021093.1	putative addiction module antidote protein	Antitoxin
G8S19_RS20905 (4329165)	4329165..4329854	+	690	WP_032942056.1	dipeptidase PepE	-
G8S19_RS20910 (4329916)	4329916..4331547	-	1632	WP_124021094.1	Na/Pi cotransporter family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4327069..4328229	1160

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (2-96)

Antitoxin

• Uncharacterized protein HI1420 (3-88)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 11997.89 Da
• Isoelectric Point: 10.1424

>T151494 WP_124021092.1 NZ_CP049738:4328467-4328784 [Citrobacter sp. SX206]
IMEILQTTVFQRWEQNLRDRRAKTLIAARLFRLANGLAGDVKPVGEGISEMRISYGPGYRIYFKQHGCRIIILLCGGDKS
SQANNITLAKVLARSLDYQETFRHE

Nucleotide

• Length: 318 bp

>T151494 NZ_CP065554:2014737-2014839 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 9791.33 Da
• Isoelectric Point: 6.2976

>AT151494 WP_124021093.1 NZ_CP049738:4328777-4329055 [Citrobacter sp. SX206]
MNKLTQYDPAAALVDDEEIAVFMADALETGDATYIAKALGVVARAKGMANIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKALGIGLTLRK

Nucleotide

• Length: 279 bp

>AT151494 NZ_CP065554:c2014846-2014701 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT