151491

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3442167..3442787 Replicon chromosome
Accession NZ_CP049738
Organism Citrobacter sp. SX206

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag G8S19_RS16750 Protein ID WP_002892050.1
Coordinates 3442569..3442787 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag G8S19_RS16745 Protein ID WP_003021733.1
Coordinates 3442167..3442541 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8S19_RS16735 (3437313) 3437313..3438506 + 1194 WP_048212410.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G8S19_RS16740 (3438529) 3438529..3441678 + 3150 WP_048212411.1 efflux RND transporter permease AcrB -
G8S19_RS16745 (3442167) 3442167..3442541 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
G8S19_RS16750 (3442569) 3442569..3442787 + 219 WP_002892050.1 HHA domain-containing protein Toxin
G8S19_RS16755 (3442976) 3442976..3443527 + 552 WP_061067437.1 maltose O-acetyltransferase -
G8S19_RS16760 (3443644) 3443644..3444114 + 471 WP_040232692.1 YlaC family protein -
G8S19_RS16765 (3444192) 3444192..3444332 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
G8S19_RS16770 (3444334) 3444334..3444594 - 261 WP_005125189.1 type B 50S ribosomal protein L31 -
G8S19_RS16775 (3444783) 3444783..3446336 + 1554 WP_253685568.1 EAL domain-containing protein -
G8S19_RS16780 (3446391) 3446391..3446744 - 354 WP_061067436.1 DUF1428 family protein -
G8S19_RS16785 (3446827) 3446827..3447438 - 612 WP_121584303.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T151491 WP_002892050.1 NZ_CP049738:3442569-3442787 [Citrobacter sp. SX206]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T151491 NZ_CP065554:354093-354440 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT151491 WP_003021733.1 NZ_CP049738:3442167-3442541 [Citrobacter sp. SX206]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT151491 NZ_CP065554:354440-354739 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References