Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3442167..3442787 Replicon chromosome
Accession NZ_CP049738
Organism Citrobacter sp. SX206

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag G8S19_RS16750 Protein ID WP_002892050.1
Coordinates 3442569..3442787 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag G8S19_RS16745 Protein ID WP_003021733.1
Coordinates 3442167..3442541 (+) Length 125 a.a.

Genomic Context

G8S19_RS16735G8S19_RS16740G8S19_RS16745G8S19_RS16750G8S19_RS16755G8S19_RS16760G8S19_RS16775G8S19_RS16765G8S19_RS16770G8S19_RS16780G8S19_RS16785
Location: 3437313..3438506 (1194 bp)
Type: Others
Protein ID: WP_048212410.1
Location: 3438529..3441678 (3150 bp)
Type: Others
Protein ID: WP_048212411.1
Location: 3442167..3442541 (375 bp)
Type: Antitoxin
Protein ID: WP_003021733.1
Location: 3442569..3442787 (219 bp)
Type: Toxin
Protein ID: WP_002892050.1
Location: 3442976..3443527 (552 bp)
Type: Others
Protein ID: WP_061067437.1
Location: 3443644..3444114 (471 bp)
Type: Others
Protein ID: WP_040232692.1
Location: 3444783..3446336 (1554 bp)
Type: Others
Protein ID: WP_253685568.1
Location: 3444192..3444332 (141 bp)
Type: Others
Protein ID: WP_005125190.1
Location: 3444334..3444594 (261 bp)
Type: Others
Protein ID: WP_005125189.1
Location: 3446391..3446744 (354 bp)
Type: Others
Protein ID: WP_061067436.1
Location: 3446827..3447438 (612 bp)
Type: Others
Protein ID: WP_121584303.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
G8S19_RS16735 (3437313)3437313..3438506+1194WP_048212410.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-
G8S19_RS16740 (3438529)3438529..3441678+3150WP_048212411.1efflux RND transporter permease AcrB-
G8S19_RS16745 (3442167)3442167..3442541+375WP_003021733.1Hha toxicity modulator TomBAntitoxin
G8S19_RS16750 (3442569)3442569..3442787+219WP_002892050.1HHA domain-containing proteinToxin
G8S19_RS16755 (3442976)3442976..3443527+552WP_061067437.1maltose O-acetyltransferase-
G8S19_RS16760 (3443644)3443644..3444114+471WP_040232692.1YlaC family protein-
G8S19_RS16765 (3444192)3444192..3444332-141WP_005125190.1type B 50S ribosomal protein L36-
G8S19_RS16770 (3444334)3444334..3444594-261WP_005125189.1type B 50S ribosomal protein L31-
G8S19_RS16775 (3444783)3444783..3446336+1554WP_253685568.1EAL domain-containing protein-
G8S19_RS16780 (3446391)3446391..3446744-354WP_061067436.1DUF1428 family protein-
G8S19_RS16785 (3446827)3446827..3447438-612WP_121584303.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T151491 WP_002892050.1 NZ_CP049738:3442569-3442787 [Citrobacter sp. SX206]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T151491 NZ_CP065554:354093-354440 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT151491 WP_003021733.1 NZ_CP049738:3442167-3442541 [Citrobacter sp. SX206]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT151491 NZ_CP065554:354440-354739 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2P8K6F2

Antitoxin

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Source
ID
Structure
AlphaFold DBR8WZW8

References