Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4132637..4133256 Replicon chromosome
Accession NZ_CP049719
Organism Klebsiella pneumoniae strain 06KM907

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag G7Z28_RS20470 Protein ID WP_002892050.1
Coordinates 4133038..4133256 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag G7Z28_RS20465 Protein ID WP_002892066.1
Coordinates 4132637..4133011 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Z28_RS20455 4127789..4128982 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G7Z28_RS20460 4129005..4132151 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
G7Z28_RS20465 4132637..4133011 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
G7Z28_RS20470 4133038..4133256 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
G7Z28_RS20475 4133415..4133981 + 567 WP_002892030.1 maltose O-acetyltransferase -
G7Z28_RS20480 4133953..4134093 - 141 WP_004147370.1 hypothetical protein -
G7Z28_RS20485 4134114..4134584 + 471 WP_002892026.1 YlaC family protein -
G7Z28_RS20490 4134559..4136010 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
G7Z28_RS20495 4136111..4136809 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
G7Z28_RS20500 4136806..4136946 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
G7Z28_RS20505 4136946..4137209 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T151468 WP_002892050.1 NZ_CP049719:4133038-4133256 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T151468 NZ_CP065531:1407195-1407608 [Ralstonia solanacearum]
TTGAGTTACCTGATCGACACCAATGTCCTGTCCGAATTGCGCCGCAAAGCGCCCGATGCGCGCGTGGTGGCCTGGATGCA
GGACCGCCCGCGCCAGTCGCTCTACCTGAGCGTGCTGACCCTGGGCGAGATTCGCAAAGGTATCGAGCGGCTGGACGACG
CGGCGCGCCGCCAGCATCTGATTGACTGGCTCGAAGTGGAACTGCCGAACTACTTTCTCGGCCGATTGCTCGACATCGAT
GCGCATACCGCCGACCGCTGGGGCCGGCTGATGTCCTCGGCCGGCCGCCCCCTGCCCGCCATCGACGGCCTGCTGGCCGC
GACCGCCCTGCAACACGACCTCACGCTGGTCACGCGCAACACCAAGGATTTCGCGGGGCTCGACGTCCAGCTCATCAACC
CATGGGAAGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT151468 WP_002892066.1 NZ_CP049719:4132637-4133011 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT151468 NZ_CP065531:1406947-1407198 [Ralstonia solanacearum]
ATGCAAAGCTGGCAAATGCAGGCCGCCAAGGCGCGGTTTTCCGATGTCGTGAAGCGGGCGGCAGACGATGGCCCGCAGGA
AATCACCGTGCATGGCCGCCCGGTGGCGGTGGTGATCTCGCGCGCACTGTTCGATCGCTTGAGCGGCGGCGGTGAGTCGC
TGGTCAGCTTCATGCGCCAATCCCCGCTGGCCGACCAGGACGATGTCGTCTTTGAGCGCGAGCGCAGCCTGCCGCGCGAG
GTCGAGTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References