Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4133806..4134425 Replicon chromosome
Accession NZ_CP049716
Organism Klebsiella pneumoniae strain 11KM256

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag G7Z27_RS20475 Protein ID WP_002892050.1
Coordinates 4134207..4134425 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag G7Z27_RS20470 Protein ID WP_002892066.1
Coordinates 4133806..4134180 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Z27_RS20460 4128958..4130151 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G7Z27_RS20465 4130174..4133320 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
G7Z27_RS20470 4133806..4134180 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
G7Z27_RS20475 4134207..4134425 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
G7Z27_RS20480 4134584..4135150 + 567 WP_002892030.1 maltose O-acetyltransferase -
G7Z27_RS20485 4135122..4135262 - 141 WP_004147370.1 hypothetical protein -
G7Z27_RS20490 4135283..4135753 + 471 WP_002892026.1 YlaC family protein -
G7Z27_RS20495 4135728..4137179 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
G7Z27_RS20500 4137280..4137978 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
G7Z27_RS20505 4137975..4138115 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
G7Z27_RS20510 4138115..4138378 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T151448 WP_002892050.1 NZ_CP049716:4134207-4134425 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T151448 NZ_CP065515:979483-979734 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT151448 WP_002892066.1 NZ_CP049716:4133806-4134180 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT151448 NZ_CP065515:979724-979906 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References