Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1640767..1641379 Replicon chromosome
Accession NZ_CP049695
Organism Streptococcus pyogenes strain ABC76

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag G8B37_RS08255 Protein ID WP_002988077.1
Coordinates 1641044..1641379 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag G8B37_RS08250 Protein ID WP_002988079.1
Coordinates 1640767..1641054 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8B37_RS08225 (G8B37_08290) 1635956..1636939 - 984 WP_011529001.1 tagatose-bisphosphate aldolase -
G8B37_RS08230 (G8B37_08295) 1636943..1637872 - 930 WP_219222214.1 tagatose-6-phosphate kinase -
G8B37_RS08235 (G8B37_08300) 1637920..1638435 - 516 WP_011529003.1 galactose-6-phosphate isomerase subunit LacB -
G8B37_RS08240 (G8B37_08305) 1638470..1638898 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
G8B37_RS08245 (G8B37_08310) 1639344..1640117 + 774 WP_011529005.1 DeoR/GlpR family DNA-binding transcription regulator -
G8B37_RS08250 (G8B37_08315) 1640767..1641054 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
G8B37_RS08255 (G8B37_08320) 1641044..1641379 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G8B37_RS08260 (G8B37_08325) 1641518..1641694 + 177 Protein_1573 tyrosine-type recombinase/integrase -
G8B37_RS08265 (G8B37_08330) 1641825..1642217 - 393 WP_002982716.1 30S ribosomal protein S9 -
G8B37_RS08270 (G8B37_08335) 1642238..1642684 - 447 WP_002982710.1 50S ribosomal protein L13 -
G8B37_RS08275 (G8B37_08340) 1642902..1643108 - 207 WP_011529007.1 helix-turn-helix transcriptional regulator -
G8B37_RS08280 (G8B37_08345) 1643105..1643803 - 699 WP_021299047.1 hypothetical protein -
G8B37_RS08285 (G8B37_08350) 1643939..1644799 - 861 WP_011529009.1 DegV family protein -
G8B37_RS08290 (G8B37_08355) 1644896..1645414 - 519 WP_011055010.1 NYN domain-containing protein -
G8B37_RS08295 (G8B37_08360) 1645418..1646164 - 747 WP_010922667.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T151431 WP_002988077.1 NZ_CP049695:1641044-1641379 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T151431 NZ_CP065467:2651895-2652113 [Klebsiella quasipneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAACAAATATGAACTTTCTGATAATGAGCTGGCGGTATTTTACTCAGCAGCCGATCATCGTCTGGCTGAAC
TGACTATGAATAAGCTGTACGATAAAATCCCGACGTCGGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT151431 WP_002988079.1 NZ_CP049695:1640767-1641054 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT151431 NZ_CP065467:2651494-2651868 [Klebsiella quasipneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATCGCACAACTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACATCGGCTGTCAATCTCCAGTTAAATGAACTGATCGAGC
ACATTGCCACATTCGCCCTTAATTATAAAATTAAGTACGCTGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACATTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGGTT
ATTTCGTTGTTTTGTCAACGCCAGCCGGGAAAATCCGGCCAGTCTTTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References