Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1627922..1628534 Replicon chromosome
Accession NZ_CP049694
Organism Streptococcus pyogenes strain ABC122

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag G8B38_RS08135 Protein ID WP_002988077.1
Coordinates 1628199..1628534 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag G8B38_RS08130 Protein ID WP_002988079.1
Coordinates 1627922..1628209 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8B38_RS08105 (G8B38_08165) 1623111..1624094 - 984 WP_011529001.1 tagatose-bisphosphate aldolase -
G8B38_RS08110 (G8B38_08170) 1624098..1625027 - 930 WP_011529002.1 tagatose-6-phosphate kinase -
G8B38_RS08115 (G8B38_08175) 1625075..1625590 - 516 WP_011529003.1 galactose-6-phosphate isomerase subunit LacB -
G8B38_RS08120 (G8B38_08180) 1625625..1626053 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
G8B38_RS08125 (G8B38_08185) 1626499..1627272 + 774 WP_011529005.1 DeoR/GlpR family DNA-binding transcription regulator -
G8B38_RS08130 (G8B38_08190) 1627922..1628209 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
G8B38_RS08135 (G8B38_08195) 1628199..1628534 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G8B38_RS08140 (G8B38_08200) 1628673..1628849 + 177 Protein_1543 tyrosine-type recombinase/integrase -
G8B38_RS08145 (G8B38_08205) 1628980..1629372 - 393 WP_002982716.1 30S ribosomal protein S9 -
G8B38_RS08150 (G8B38_08210) 1629393..1629839 - 447 WP_002982710.1 50S ribosomal protein L13 -
G8B38_RS08155 (G8B38_08215) 1630057..1630263 - 207 WP_011529007.1 helix-turn-helix transcriptional regulator -
G8B38_RS08160 (G8B38_08220) 1630260..1630958 - 699 WP_021299047.1 hypothetical protein -
G8B38_RS08165 (G8B38_08225) 1631094..1631954 - 861 WP_011529009.1 DegV family protein -
G8B38_RS08170 (G8B38_08230) 1632051..1632569 - 519 WP_011055010.1 NYN domain-containing protein -
G8B38_RS08175 (G8B38_08235) 1632573..1633319 - 747 WP_010922667.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T151430 WP_002988077.1 NZ_CP049694:1628199-1628534 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T151430 NZ_CP065467:c2510847-2510530 [Klebsiella quasipneumoniae]
ATGTTCAGAATGGTTGTGCATGTGGACGTTAAAAAGGAGTTGCAGGCGCTTCCGGCTATTGTCCAGGCTAAGATGATCAG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGATAGTAAACCGCTTGGACAAGGGCTATTTGAAA
TTCGAGCGTTAGGTTCGGTACAGGGGCGGGGGATCTACGTTTTTCAGCAAAACAAAACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAATCCCGTTATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT151430 WP_002988079.1 NZ_CP049694:1627922-1628209 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT151430 NZ_CP065467:c2510537-2510250 [Klebsiella quasipneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGCTGCGTTCGATGC
GCAAGAACGTAAGCACCGATTACGTACTATGCTGGCACAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCACCAGCCTGGATACCTTAACGCGA
TACGCGCTAGCGTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References