151428

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1643880..1644492 Replicon chromosome
Accession NZ_CP049692
Organism Streptococcus pyogenes strain ABC157

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag G8B40_RS08300 Protein ID WP_002988077.1
Coordinates 1644157..1644492 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag G8B40_RS08295 Protein ID WP_002988079.1
Coordinates 1643880..1644167 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8B40_RS08270 (G8B40_08330) 1639069..1640052 - 984 WP_011529001.1 tagatose-bisphosphate aldolase -
G8B40_RS08275 (G8B40_08335) 1640056..1640985 - 930 WP_011529002.1 tagatose-6-phosphate kinase -
G8B40_RS08280 (G8B40_08340) 1641033..1641548 - 516 WP_011529003.1 galactose-6-phosphate isomerase subunit LacB -
G8B40_RS08285 (G8B40_08345) 1641583..1642011 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
G8B40_RS08290 (G8B40_08350) 1642457..1643230 + 774 WP_011529005.1 DeoR/GlpR family DNA-binding transcription regulator -
G8B40_RS08295 (G8B40_08355) 1643880..1644167 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
G8B40_RS08300 (G8B40_08360) 1644157..1644492 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G8B40_RS08305 (G8B40_08365) 1644631..1644807 + 177 Protein_1580 tyrosine-type recombinase/integrase -
G8B40_RS08310 (G8B40_08370) 1644938..1645330 - 393 WP_002982716.1 30S ribosomal protein S9 -
G8B40_RS08315 (G8B40_08375) 1645351..1645797 - 447 WP_002982710.1 50S ribosomal protein L13 -
G8B40_RS08320 (G8B40_08380) 1646015..1646221 - 207 WP_011529007.1 helix-turn-helix transcriptional regulator -
G8B40_RS08325 (G8B40_08385) 1646218..1646916 - 699 WP_021299047.1 hypothetical protein -
G8B40_RS08330 (G8B40_08390) 1647052..1647912 - 861 WP_011529009.1 DegV family protein -
G8B40_RS08335 (G8B40_08395) 1648009..1648527 - 519 WP_011055010.1 NYN domain-containing protein -
G8B40_RS08340 (G8B40_08400) 1648531..1649277 - 747 WP_010922667.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T151428 WP_002988077.1 NZ_CP049692:1644157-1644492 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T151428 NZ_CP065467:651057-651159 [Klebsiella quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT151428 WP_002988079.1 NZ_CP049692:1643880-1644167 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT151428 NZ_CP065467:c651163-651016 [Klebsiella quasipneumoniae]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References