Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1585467..1586079 Replicon chromosome
Accession NZ_CP049691
Organism Streptococcus pyogenes strain ABC199

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag G8B41_RS07850 Protein ID WP_002988077.1
Coordinates 1585744..1586079 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag G8B41_RS07845 Protein ID WP_002988079.1
Coordinates 1585467..1585754 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8B41_RS07820 (G8B41_07880) 1580656..1581639 - 984 WP_011529001.1 tagatose-bisphosphate aldolase -
G8B41_RS07825 (G8B41_07885) 1581643..1582572 - 930 WP_011529002.1 tagatose-6-phosphate kinase -
G8B41_RS07830 (G8B41_07890) 1582620..1583135 - 516 WP_011529003.1 galactose-6-phosphate isomerase subunit LacB -
G8B41_RS07835 (G8B41_07895) 1583170..1583598 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
G8B41_RS07840 (G8B41_07900) 1584044..1584817 + 774 WP_011529005.1 DeoR/GlpR family DNA-binding transcription regulator -
G8B41_RS07845 (G8B41_07905) 1585467..1585754 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
G8B41_RS07850 (G8B41_07910) 1585744..1586079 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G8B41_RS07855 (G8B41_07915) 1586218..1586394 + 177 Protein_1485 tyrosine-type recombinase/integrase -
G8B41_RS07860 (G8B41_07920) 1586525..1586917 - 393 WP_002982716.1 30S ribosomal protein S9 -
G8B41_RS07865 (G8B41_07925) 1586938..1587384 - 447 WP_002982710.1 50S ribosomal protein L13 -
G8B41_RS07870 (G8B41_07930) 1587602..1587808 - 207 WP_011529007.1 helix-turn-helix transcriptional regulator -
G8B41_RS07875 (G8B41_07935) 1587805..1588503 - 699 WP_021299047.1 hypothetical protein -
G8B41_RS07880 (G8B41_07940) 1588639..1589499 - 861 WP_011529009.1 DegV family protein -
G8B41_RS07885 (G8B41_07945) 1589596..1590114 - 519 WP_011055010.1 NYN domain-containing protein -
G8B41_RS07890 (G8B41_07950) 1590118..1590864 - 747 WP_010922667.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T151427 WP_002988077.1 NZ_CP049691:1585744-1586079 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T151427 NZ_CP065466:c54762-54613 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT151427 WP_002988079.1 NZ_CP049691:1585467-1585754 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT151427 NZ_CP065466:54807-54866 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References