Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1684927..1685539 Replicon chromosome
Accession NZ_CP049689
Organism Streptococcus pyogenes strain ABC221

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag G8B43_RS08600 Protein ID WP_002988077.1
Coordinates 1685204..1685539 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag G8B43_RS08595 Protein ID WP_002988079.1
Coordinates 1684927..1685214 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8B43_RS08570 (G8B43_08635) 1680116..1681099 - 984 WP_011529001.1 tagatose-bisphosphate aldolase -
G8B43_RS08575 (G8B43_08640) 1681103..1682032 - 930 WP_011529002.1 tagatose-6-phosphate kinase -
G8B43_RS08580 (G8B43_08645) 1682080..1682595 - 516 WP_011529003.1 galactose-6-phosphate isomerase subunit LacB -
G8B43_RS08585 (G8B43_08650) 1682630..1683058 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
G8B43_RS08590 (G8B43_08655) 1683504..1684277 + 774 WP_011529005.1 DeoR/GlpR family DNA-binding transcription regulator -
G8B43_RS08595 (G8B43_08660) 1684927..1685214 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
G8B43_RS08600 (G8B43_08665) 1685204..1685539 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G8B43_RS08605 (G8B43_08670) 1685678..1685854 + 177 Protein_1643 tyrosine-type recombinase/integrase -
G8B43_RS08610 (G8B43_08675) 1685985..1686377 - 393 WP_002982716.1 30S ribosomal protein S9 -
G8B43_RS08615 (G8B43_08680) 1686398..1686844 - 447 WP_002982710.1 50S ribosomal protein L13 -
G8B43_RS08620 (G8B43_08685) 1687062..1687268 - 207 WP_011529007.1 helix-turn-helix transcriptional regulator -
G8B43_RS08625 (G8B43_08690) 1687265..1687963 - 699 WP_021299047.1 hypothetical protein -
G8B43_RS08630 (G8B43_08695) 1688099..1688959 - 861 WP_011529009.1 DegV family protein -
G8B43_RS08635 (G8B43_08700) 1689056..1689574 - 519 WP_011055010.1 NYN domain-containing protein -
G8B43_RS08640 (G8B43_08705) 1689578..1690324 - 747 WP_010922667.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T151425 WP_002988077.1 NZ_CP049689:1685204-1685539 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T151425 NZ_CP065465:c2430-2080 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT151425 WP_002988079.1 NZ_CP049689:1684927-1685214 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT151425 NZ_CP065465:c2075-1773 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References