151424

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1639471..1640083 Replicon chromosome
Accession NZ_CP049688
Organism Streptococcus pyogenes strain ABC245

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag G8B44_RS08265 Protein ID WP_002988077.1
Coordinates 1639748..1640083 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag G8B44_RS08260 Protein ID WP_002988079.1
Coordinates 1639471..1639758 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8B44_RS08235 (G8B44_08295) 1634660..1635643 - 984 WP_011529001.1 tagatose-bisphosphate aldolase -
G8B44_RS08240 (G8B44_08300) 1635647..1636576 - 930 WP_011529002.1 tagatose-6-phosphate kinase -
G8B44_RS08245 (G8B44_08305) 1636624..1637139 - 516 WP_011529003.1 galactose-6-phosphate isomerase subunit LacB -
G8B44_RS08250 (G8B44_08310) 1637174..1637602 - 429 WP_219233111.1 galactose-6-phosphate isomerase subunit LacA -
G8B44_RS08255 (G8B44_08315) 1638048..1638821 + 774 WP_011529005.1 DeoR/GlpR family DNA-binding transcription regulator -
G8B44_RS08260 (G8B44_08320) 1639471..1639758 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
G8B44_RS08265 (G8B44_08325) 1639748..1640083 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G8B44_RS08270 (G8B44_08330) 1640222..1640398 + 177 Protein_1577 tyrosine-type recombinase/integrase -
G8B44_RS08275 (G8B44_08335) 1640529..1640921 - 393 WP_002982716.1 30S ribosomal protein S9 -
G8B44_RS08280 (G8B44_08340) 1640942..1641388 - 447 WP_002982710.1 50S ribosomal protein L13 -
G8B44_RS08285 (G8B44_08345) 1641606..1641812 - 207 WP_011529007.1 helix-turn-helix transcriptional regulator -
G8B44_RS08290 (G8B44_08350) 1641809..1642507 - 699 WP_021299047.1 hypothetical protein -
G8B44_RS08295 (G8B44_08355) 1642643..1643503 - 861 WP_011529009.1 DegV family protein -
G8B44_RS08300 (G8B44_08360) 1643600..1644118 - 519 WP_011055010.1 NYN domain-containing protein -
G8B44_RS08305 (G8B44_08365) 1644122..1644868 - 747 WP_010922667.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T151424 WP_002988077.1 NZ_CP049688:1639748-1640083 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T151424 NZ_CP065464:5407551-5407934 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT151424 WP_002988079.1 NZ_CP049688:1639471-1639758 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT151424 NZ_CP065464:5407309-5407551 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References