Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1585513..1586125 Replicon chromosome
Accession NZ_CP049686
Organism Streptococcus pyogenes strain TSPY637

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag G8B46_RS07845 Protein ID WP_002988077.1
Coordinates 1585790..1586125 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag G8B46_RS07840 Protein ID WP_002988079.1
Coordinates 1585513..1585800 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G8B46_RS07815 (G8B46_07880) 1580702..1581685 - 984 WP_011529001.1 tagatose-bisphosphate aldolase -
G8B46_RS07820 (G8B46_07885) 1581689..1582618 - 930 WP_011529002.1 tagatose-6-phosphate kinase -
G8B46_RS07825 (G8B46_07890) 1582666..1583181 - 516 WP_011529003.1 galactose-6-phosphate isomerase subunit LacB -
G8B46_RS07830 (G8B46_07895) 1583216..1583644 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
G8B46_RS07835 (G8B46_07900) 1584090..1584863 + 774 WP_011529005.1 DeoR/GlpR family DNA-binding transcription regulator -
G8B46_RS07840 (G8B46_07905) 1585513..1585800 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
G8B46_RS07845 (G8B46_07910) 1585790..1586125 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G8B46_RS07850 (G8B46_07915) 1586264..1586440 + 177 Protein_1485 tyrosine-type recombinase/integrase -
G8B46_RS07855 (G8B46_07920) 1586571..1586963 - 393 WP_002982716.1 30S ribosomal protein S9 -
G8B46_RS07860 (G8B46_07925) 1586984..1587430 - 447 WP_002982710.1 50S ribosomal protein L13 -
G8B46_RS07865 (G8B46_07930) 1587648..1587854 - 207 WP_011529007.1 helix-turn-helix transcriptional regulator -
G8B46_RS07870 (G8B46_07935) 1587851..1588549 - 699 WP_021299047.1 hypothetical protein -
G8B46_RS07875 (G8B46_07940) 1588685..1589545 - 861 WP_011529009.1 DegV family protein -
G8B46_RS07880 (G8B46_07945) 1589642..1590160 - 519 WP_011055010.1 NYN domain-containing protein -
G8B46_RS07885 (G8B46_07950) 1590164..1590910 - 747 WP_010922667.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T151422 WP_002988077.1 NZ_CP049686:1585790-1586125 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T151422 NZ_CP065464:c4973790-4973443 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT151422 WP_002988079.1 NZ_CP049686:1585513-1585800 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT151422 NZ_CP065464:c4973443-4973144 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References