Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1074855..1075462 Replicon chromosome
Accession NZ_CP049684
Organism Polynucleobacter paneuropaeus strain AP-Creno-5A-D2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag C2742_RS05410 Protein ID WP_112204489.1
Coordinates 1074855..1075145 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag C2742_RS05415 Protein ID WP_112204491.1
Coordinates 1075154..1075462 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2742_RS05385 (C2742_05390) 1070172..1070789 + 618 WP_112209453.1 response regulator -
C2742_RS05390 (C2742_05395) 1070780..1071097 - 318 WP_158525188.1 helix-turn-helix domain-containing protein -
C2742_RS05395 (C2742_05400) 1071168..1071953 - 786 WP_215279158.1 ATP-binding protein -
C2742_RS05400 (C2742_05405) 1072791..1073918 + 1128 WP_215278663.1 quinolinate synthase NadA -
C2742_RS05405 (C2742_05410) 1073925..1074779 + 855 WP_215278664.1 carboxylating nicotinate-nucleotide diphosphorylase -
C2742_RS05410 (C2742_05415) 1074855..1075145 + 291 WP_112204489.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2742_RS05415 (C2742_05420) 1075154..1075462 + 309 WP_112204491.1 putative addiction module antidote protein Antitoxin
C2742_RS05420 (C2742_05425) 1075474..1077120 - 1647 WP_112209458.1 L-aspartate oxidase -
C2742_RS05425 (C2742_05430) 1077161..1077439 - 279 WP_112204496.1 type II toxin-antitoxin system RelE/ParE family toxin -
C2742_RS05430 (C2742_05435) 1077439..1077666 - 228 WP_112204498.1 ParD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11102.00 Da        Isoelectric Point: 10.3340

>T151420 WP_112204489.1 NZ_CP049684:1074855-1075145 [Polynucleobacter paneuropaeus]
MLEIRKTEEFKAWLDSLHDLMGRAKIQARIKRLAEGNPGNTKSVGSKVFEMKIDFGPGYRIYYTQHENVMYLLLIGGNKR
TQVKDIQIAKYLAKNI

Download         Length: 291 bp

>T151420 NZ_CP065464:c4452738-4452331 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10972.78 Da        Isoelectric Point: 9.8628

>AT151420 WP_112204491.1 NZ_CP049684:1075154-1075462 [Polynucleobacter paneuropaeus]
MKKTIISPYDVVEHLRTPKEMALYLQACIEESNGDAAFIARALGDIARAKGMAQVAKESGLSRESLYKALSGDRIPGFDT
VLKVLAALGLSLHTKPTSKARA

Download         Length: 309 bp

>AT151420 NZ_CP065464:c4452985-4452719 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References