Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 645347..645878 Replicon chromosome
Accession NZ_CP049683
Organism Polynucleobacter paneuropaeus strain AP-RePozz10-5-G5

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag C2754_RS03360 Protein ID WP_112203740.1
Coordinates 645347..645628 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag C2754_RS03365 Protein ID WP_112203742.1
Coordinates 645615..645878 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2754_RS03345 (C2754_03350) 642707..643210 + 504 WP_112237935.1 DUF1993 domain-containing protein -
C2754_RS03350 (C2754_03355) 643231..644187 - 957 WP_215286198.1 tripartite tricarboxylate transporter substrate binding protein -
C2754_RS03355 (C2754_03360) 644184..645251 - 1068 WP_215286199.1 tartrate dehydrogenase -
C2754_RS03360 (C2754_03365) 645347..645628 - 282 WP_112203740.1 type II toxin-antitoxin system YafQ family toxin Toxin
C2754_RS03365 (C2754_03370) 645615..645878 - 264 WP_112203742.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C2754_RS03370 (C2754_03375) 645993..646478 + 486 WP_112318202.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
C2754_RS03375 (C2754_03380) 646475..647764 + 1290 WP_215286200.1 Y-family DNA polymerase -
C2754_RS08345 647790..647924 + 135 WP_264080452.1 hypothetical protein -
C2754_RS03380 (C2754_03385) 648060..648512 + 453 WP_112318204.1 Smr/MutS family protein -
C2754_RS08350 648667..648798 + 132 WP_255880032.1 hypothetical protein -
C2754_RS03385 (C2754_03390) 648803..649093 + 291 WP_215274655.1 BrnT family toxin -
C2754_RS03390 (C2754_03395) 649053..649364 + 312 WP_112237987.1 BrnA antitoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-76)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11474.14 Da        Isoelectric Point: 9.2930

>T151415 WP_112203740.1 NZ_CP049683:c645628-645347 [Polynucleobacter paneuropaeus]
MRTTEYTKKFRKDYKRELKGRYRLTLARDFQETLDYLINDWDLPYRYHDHPLVGDWVDHRDCHIKPDLVLIYRKPDQRIL
QLVRLGSHSELSL

Download         Length: 282 bp

>T151415 NZ_CP065464:398644-398928 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9362.78 Da        Isoelectric Point: 5.0651

>AT151415 WP_112203742.1 NZ_CP049683:c645878-645615 [Polynucleobacter paneuropaeus]
MTANAVVRARINGDIKEEASAILAAMGLTPSDAFRILMTRIAREKALPFEPLSPNAETIAAMKEARKGNLKSFTSVNDLM
ADLNADD

Download         Length: 264 bp

>AT151415 NZ_CP065464:398412-398654 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References