Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1047319..1047926 Replicon chromosome
Accession NZ_CP049682
Organism Polynucleobacter paneuropaeus strain AP-RePozz9-10-D2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag C2750_RS05280 Protein ID WP_112204489.1
Coordinates 1047319..1047609 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag C2750_RS05285 Protein ID WP_112204491.1
Coordinates 1047618..1047926 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2750_RS05255 (C2750_05260) 1042635..1043252 + 618 WP_112209453.1 response regulator -
C2750_RS05260 (C2750_05265) 1043243..1043560 - 318 WP_158525188.1 helix-turn-helix domain-containing protein -
C2750_RS05265 (C2750_05270) 1043608..1044417 - 810 WP_215278662.1 ATP-binding protein -
C2750_RS05270 (C2750_05275) 1045255..1046382 + 1128 WP_215278663.1 quinolinate synthase NadA -
C2750_RS05275 (C2750_05280) 1046389..1047243 + 855 WP_215278664.1 carboxylating nicotinate-nucleotide diphosphorylase -
C2750_RS05280 (C2750_05285) 1047319..1047609 + 291 WP_112204489.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2750_RS05285 (C2750_05290) 1047618..1047926 + 309 WP_112204491.1 putative addiction module antidote protein Antitoxin
C2750_RS05290 (C2750_05295) 1047938..1049584 - 1647 WP_112209458.1 L-aspartate oxidase -
C2750_RS05295 (C2750_05300) 1049625..1049903 - 279 WP_112204496.1 type II toxin-antitoxin system RelE/ParE family toxin -
C2750_RS05300 (C2750_05305) 1049903..1050130 - 228 WP_112204498.1 ParD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11102.00 Da        Isoelectric Point: 10.3340

>T151412 WP_112204489.1 NZ_CP049682:1047319-1047609 [Polynucleobacter paneuropaeus]
MLEIRKTEEFKAWLDSLHDLMGRAKIQARIKRLAEGNPGNTKSVGSKVFEMKIDFGPGYRIYYTQHENVMYLLLIGGNKR
TQVKDIQIAKYLAKNI

Download         Length: 291 bp

>T151412 NZ_CP065462:170137-170619 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10972.78 Da        Isoelectric Point: 9.8628

>AT151412 WP_112204491.1 NZ_CP049682:1047618-1047926 [Polynucleobacter paneuropaeus]
MKKTIISPYDVVEHLRTPKEMALYLQACIEESNGDAAFIARALGDIARAKGMAQVAKESGLSRESLYKALSGDRIPGFDT
VLKVLAALGLSLHTKPTSKARA

Download         Length: 309 bp

>AT151412 NZ_CP065462:169883-170149 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References