Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1065980..1066587 Replicon chromosome
Accession NZ_CP049681
Organism Polynucleobacter paneuropaeus strain AP-RePozz9-5-D10

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag C2752_RS05370 Protein ID WP_112204489.1
Coordinates 1065980..1066270 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag C2752_RS05375 Protein ID WP_112204491.1
Coordinates 1066279..1066587 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2752_RS05345 (C2752_05340) 1061296..1061913 + 618 WP_112209453.1 response regulator -
C2752_RS05350 (C2752_05345) 1061904..1062221 - 318 WP_158525188.1 helix-turn-helix domain-containing protein -
C2752_RS05355 (C2752_05350) 1062269..1063078 - 810 WP_215278662.1 ATP-binding protein -
C2752_RS05360 (C2752_05355) 1063916..1065043 + 1128 WP_215278663.1 quinolinate synthase NadA -
C2752_RS05365 (C2752_05360) 1065050..1065904 + 855 WP_215278664.1 carboxylating nicotinate-nucleotide diphosphorylase -
C2752_RS05370 (C2752_05365) 1065980..1066270 + 291 WP_112204489.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2752_RS05375 (C2752_05370) 1066279..1066587 + 309 WP_112204491.1 putative addiction module antidote protein Antitoxin
C2752_RS05380 (C2752_05375) 1066599..1068245 - 1647 WP_112209458.1 L-aspartate oxidase -
C2752_RS05385 (C2752_05380) 1068286..1068564 - 279 WP_112204496.1 type II toxin-antitoxin system RelE/ParE family toxin -
C2752_RS05390 (C2752_05385) 1068564..1068791 - 228 WP_112204498.1 ParD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11102.00 Da        Isoelectric Point: 10.3340

>T151408 WP_112204489.1 NZ_CP049681:1065980-1066270 [Polynucleobacter paneuropaeus]
MLEIRKTEEFKAWLDSLHDLMGRAKIQARIKRLAEGNPGNTKSVGSKVFEMKIDFGPGYRIYYTQHENVMYLLLIGGNKR
TQVKDIQIAKYLAKNI

Download         Length: 291 bp

>T151408 NZ_CP065460:c5224171-5223887 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10972.78 Da        Isoelectric Point: 9.8628

>AT151408 WP_112204491.1 NZ_CP049681:1066279-1066587 [Polynucleobacter paneuropaeus]
MKKTIISPYDVVEHLRTPKEMALYLQACIEESNGDAAFIARALGDIARAKGMAQVAKESGLSRESLYKALSGDRIPGFDT
VLKVLAALGLSLHTKPTSKARA

Download         Length: 309 bp

>AT151408 NZ_CP065460:c5224403-5224161 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References