Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1040701..1041308 Replicon chromosome
Accession NZ_CP049679
Organism Polynucleobacter paneuropaeus strain AP-Creno-20-G10

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag G7Z35_RS05265 Protein ID WP_112204489.1
Coordinates 1040701..1040991 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag G7Z35_RS05270 Protein ID WP_112204491.1
Coordinates 1041000..1041308 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Z35_RS05240 (G7Z35_05255) 1036018..1036635 + 618 WP_112209453.1 response regulator -
G7Z35_RS05245 (G7Z35_05260) 1036626..1036943 - 318 WP_158525188.1 helix-turn-helix domain-containing protein -
G7Z35_RS05250 (G7Z35_05265) 1037014..1037799 - 786 WP_215279158.1 ATP-binding protein -
G7Z35_RS05255 (G7Z35_05270) 1038637..1039764 + 1128 WP_215278663.1 quinolinate synthase NadA -
G7Z35_RS05260 (G7Z35_05275) 1039771..1040625 + 855 WP_215278664.1 carboxylating nicotinate-nucleotide diphosphorylase -
G7Z35_RS05265 (G7Z35_05280) 1040701..1040991 + 291 WP_112204489.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G7Z35_RS05270 (G7Z35_05285) 1041000..1041308 + 309 WP_112204491.1 putative addiction module antidote protein Antitoxin
G7Z35_RS05275 (G7Z35_05290) 1041320..1042966 - 1647 WP_112209458.1 L-aspartate oxidase -
G7Z35_RS05280 (G7Z35_05295) 1043007..1043285 - 279 WP_112204496.1 type II toxin-antitoxin system RelE/ParE family toxin -
G7Z35_RS05285 (G7Z35_05300) 1043285..1043512 - 228 WP_112204498.1 ParD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11102.00 Da        Isoelectric Point: 10.3340

>T151400 WP_112204489.1 NZ_CP049679:1040701-1040991 [Polynucleobacter paneuropaeus]
MLEIRKTEEFKAWLDSLHDLMGRAKIQARIKRLAEGNPGNTKSVGSKVFEMKIDFGPGYRIYYTQHENVMYLLLIGGNKR
TQVKDIQIAKYLAKNI

Download         Length: 291 bp

>T151400 NZ_CP065460:575719-576087 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10972.78 Da        Isoelectric Point: 9.8628

>AT151400 WP_112204491.1 NZ_CP049679:1041000-1041308 [Polynucleobacter paneuropaeus]
MKKTIISPYDVVEHLRTPKEMALYLQACIEESNGDAAFIARALGDIARAKGMAQVAKESGLSRESLYKALSGDRIPGFDT
VLKVLAALGLSLHTKPTSKARA

Download         Length: 309 bp

>AT151400 NZ_CP065460:575501-575722 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References