Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 638798..639329 Replicon chromosome
Accession NZ_CP049679
Organism Polynucleobacter paneuropaeus strain AP-Creno-20-G10

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag G7Z35_RS03345 Protein ID WP_112203740.1
Coordinates 638798..639079 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag G7Z35_RS03350 Protein ID WP_112313890.1
Coordinates 639066..639329 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Z35_RS03330 (G7Z35_03345) 636158..636661 + 504 WP_215279467.1 DUF1993 domain-containing protein -
G7Z35_RS03335 (G7Z35_03350) 636682..637638 - 957 WP_215275391.1 tripartite tricarboxylate transporter substrate binding protein -
G7Z35_RS03340 (G7Z35_03355) 637635..638702 - 1068 WP_112294735.1 tartrate dehydrogenase -
G7Z35_RS03345 (G7Z35_03360) 638798..639079 - 282 WP_112203740.1 type II toxin-antitoxin system YafQ family toxin Toxin
G7Z35_RS03350 (G7Z35_03365) 639066..639329 - 264 WP_112313890.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
G7Z35_RS03355 (G7Z35_03370) 639444..639929 + 486 WP_112318202.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
G7Z35_RS03360 (G7Z35_03375) 639926..641215 + 1290 WP_215279468.1 Y-family DNA polymerase -
G7Z35_RS08285 641241..641375 + 135 WP_264080447.1 hypothetical protein -
G7Z35_RS03365 (G7Z35_03380) 641511..641963 + 453 WP_112318204.1 Smr/MutS family protein -
G7Z35_RS08290 642118..642249 + 132 WP_255880032.1 hypothetical protein -
G7Z35_RS03370 (G7Z35_03385) 642290..642580 + 291 WP_215279524.1 BrnT family toxin -
G7Z35_RS03375 (G7Z35_03390) 642540..642851 + 312 WP_112203751.1 BrnA antitoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-76)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11474.14 Da        Isoelectric Point: 9.2930

>T151399 WP_112203740.1 NZ_CP049679:c639079-638798 [Polynucleobacter paneuropaeus]
MRTTEYTKKFRKDYKRELKGRYRLTLARDFQETLDYLINDWDLPYRYHDHPLVGDWVDHRDCHIKPDLVLIYRKPDQRIL
QLVRLGSHSELSL

Download         Length: 282 bp

>T151399 NZ_CP065460:c168995-168612 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9392.81 Da        Isoelectric Point: 5.0651

>AT151399 WP_112313890.1 NZ_CP049679:c639329-639066 [Polynucleobacter paneuropaeus]
MTANAVVRARINGDIKEEASAILAAMGLTPSDAFRILMTRIAREKTLPFEPLSPNAETIAAMKEARKGNLKSFTSVNDLM
ADLNADD

Download         Length: 264 bp

>AT151399 NZ_CP065460:c169237-168995 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References