Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 126799..127337 Replicon chromosome
Accession NZ_CP049679
Organism Polynucleobacter paneuropaeus strain AP-Creno-20-G10

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G7Z35_RS00735 Protein ID WP_112313599.1
Coordinates 126799..127125 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G7Z35_RS00740 Protein ID WP_112202759.1
Coordinates 127122..127337 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Z35_RS00715 (G7Z35_00715) 122849..123157 - 309 WP_112202749.1 Grx4 family monothiol glutaredoxin -
G7Z35_RS00720 (G7Z35_00720) 123240..124082 - 843 WP_112202751.1 peptide chain release factor N(5)-glutamine methyltransferase -
G7Z35_RS00725 (G7Z35_00725) 124089..125168 - 1080 WP_112313597.1 peptide chain release factor 1 -
G7Z35_RS00730 (G7Z35_00730) 125169..126485 - 1317 WP_215279310.1 glutamyl-tRNA reductase -
G7Z35_RS00735 (G7Z35_00740) 126799..127125 - 327 WP_112313599.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G7Z35_RS00740 (G7Z35_00745) 127122..127337 - 216 WP_112202759.1 antitoxin MazE family protein Antitoxin
G7Z35_RS00745 (G7Z35_00750) 127454..128176 - 723 WP_215279311.1 uracil-DNA glycosylase -
G7Z35_RS00750 (G7Z35_00755) 128187..129968 - 1782 WP_215279312.1 PDZ domain-containing protein -
G7Z35_RS00755 (G7Z35_00760) 129985..130704 - 720 WP_112208732.1 DsbC family protein -
G7Z35_RS00760 (G7Z35_00765) 130697..131971 - 1275 WP_112208733.1 FAD-dependent monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(8-70)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11755.76 Da        Isoelectric Point: 8.7358

>T151396 WP_112313599.1 NZ_CP049679:c127125-126799 [Polynucleobacter paneuropaeus]
MKRGSLVTIAMQGDFGKPRPALVIQSDVFNEVHSTVTVLLVSGEKVDAPLFRLDILPSPENGLTKLSQIQVDKIMSVRSE
KIGSKIGQLDDAEMLRVNRALGLWLGLG

Download         Length: 327 bp

>T151396 NZ_CP065457:4933126-4933509 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7870.98 Da        Isoelectric Point: 9.4082

>AT151396 WP_112202759.1 NZ_CP049679:c127337-127122 [Polynucleobacter paneuropaeus]
MGSSTAIRVQKHRVSLRNAGLRPIQLWVPDTRVPGFKKECARQSSLAAMTDRADRDLMSFLDDALNDLGGE

Download         Length: 216 bp

>AT151396 NZ_CP065457:4932884-4933126 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References