Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3430027..3430648 Replicon chromosome
Accession NZ_CP049608
Organism Atlantibacter hermannii strain 78-1320

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag FV156_RS16385 Protein ID WP_001291435.1
Coordinates 3430027..3430245 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag FV156_RS16390 Protein ID WP_043866710.1
Coordinates 3430274..3430648 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FV156_RS16350 3425497..3425877 + 381 WP_040459530.1 hypothetical protein -
FV156_RS16355 3426250..3426501 + 252 WP_148052435.1 hypothetical protein -
FV156_RS16360 3426498..3426716 + 219 WP_002463728.1 hypothetical protein -
FV156_RS16365 3426855..3428405 - 1551 WP_165431904.1 EAL domain-containing protein -
FV156_RS16370 3428660..3428920 + 261 WP_002463724.1 type B 50S ribosomal protein L31 -
FV156_RS16375 3428923..3429063 + 141 WP_061708247.1 type B 50S ribosomal protein L36 -
FV156_RS16380 3429099..3429566 - 468 WP_002463722.1 YlaC family protein -
FV156_RS16385 3430027..3430245 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
FV156_RS16390 3430274..3430648 - 375 WP_043866710.1 Hha toxicity modulator TomB Antitoxin
FV156_RS16395 3431120..3434269 - 3150 WP_002463716.1 multidrug efflux RND transporter permease subunit -
FV156_RS16400 3434292..3435488 - 1197 WP_002463714.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T151385 WP_001291435.1 NZ_CP049608:c3430245-3430027 [Atlantibacter hermannii]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T151385 NZ_CP065457:272786-273070 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGTGAATAAACGGCTCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14380.16 Da        Isoelectric Point: 5.1259

>AT151385 WP_043866710.1 NZ_CP049608:c3430648-3430274 [Atlantibacter hermannii]
MDEYSPKRHDIAQLKFLCENLYHDCLITLGDSNHGWVNDPTSAINLQLNELIEHIASFALNYKIKHDEDNALIEHVDEYL
DDTFMLFSNYGISAQDLQKWRKSGNRLFRCFVNVSKANPVSLSF

Download         Length: 375 bp

>AT151385 NZ_CP065457:272554-272796 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGTGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References