Detailed information of TA system TA151384

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 2538558..2539144
• Replicon: chromosome
• Accession: NZ_CP049608
• Organism: Atlantibacter hermannii strain 78-1320

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: FV156_RS12040
• Protein ID: WP_165431597.1
• Coordinates: 2538776..2539144 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: H5V3H8
• Locus tag: FV156_RS12035
• Protein ID: WP_002436532.1
• Coordinates: 2538558..2538779 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FV156_RS12010	2533641..2534756	+	1116	WP_142984558.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
FV156_RS12015	2534792..2535718	+	927	WP_002436536.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
FV156_RS12020	2535715..2536992	+	1278	WP_002436535.1	high-affinity branched-chain amino acid ABC transporter permease LivM	-
FV156_RS12025	2536989..2537756	+	768	WP_002436534.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
FV156_RS12030	2537758..2538471	+	714	WP_040459930.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
FV156_RS12035	2538558..2538779	+	222	WP_002436532.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FV156_RS12040	2538776..2539144	+	369	WP_165431597.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
FV156_RS12045	2539321..2540634	+	1314	WP_148052156.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
FV156_RS12050	2540695..2541582	+	888	WP_043866379.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
FV156_RS12055	2541579..2542424	+	846	WP_165431598.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
FV156_RS12060	2542434..2543501	+	1068	WP_002436522.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2535715..2544238	8523

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (6-121)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-53)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13614.92 Da
• Isoelectric Point: 8.5565

>T151384 WP_165431597.1 NZ_CP049608:2538776-2539144 [Atlantibacter hermannii]
MTIQFISAEEIIRFHDRLLAVTPGVPGMVDPSRAEALLYRVLNKYEYEGVNDPWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGITLPANPAFVELTVAAAAGQLSLEEIARQLRK

Nucleotide

• Length: 369 bp

>T151384 NZ_CP065457:109415-110332 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8091.20 Da
• Isoelectric Point: 5.6512

>AT151384 WP_002436532.1 NZ_CP049608:2538558-2538779 [Atlantibacter hermannii]
MQTMNYSEARQNLAAALETAALGTPVTITRRGHKPAVIISAEEFERYQQAKMDAEFAAIMAIHGNEIRELADK

Nucleotide

• Length: 222 bp

>AT151384 NZ_CP065457:108651-109409 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: H5V3H8