Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1437467..1438133 Replicon chromosome
Accession NZ_CP049608
Organism Atlantibacter hermannii strain 78-1320

Toxin (Protein)


Gene name cptA Uniprot ID A0A447LT15
Locus tag FV156_RS06960 Protein ID WP_040459615.1
Coordinates 1437467..1437886 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H5V069
Locus tag FV156_RS06965 Protein ID WP_002434469.1
Coordinates 1437867..1438133 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FV156_RS06940 1433459..1435192 - 1734 WP_148051815.1 single-stranded-DNA-specific exonuclease RecJ -
FV156_RS06945 1435196..1435915 - 720 WP_002434476.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FV156_RS06950 1435941..1436840 - 900 WP_002434475.1 site-specific tyrosine recombinase XerD -
FV156_RS06955 1436942..1437463 + 522 WP_002434473.1 flavodoxin FldB -
FV156_RS06960 1437467..1437886 - 420 WP_040459615.1 protein YgfX Toxin
FV156_RS06965 1437867..1438133 - 267 WP_002434469.1 FAD assembly factor SdhE Antitoxin
FV156_RS06970 1438392..1439378 + 987 WP_043865941.1 tRNA-modifying protein YgfZ -
FV156_RS06975 1439536..1440195 - 660 WP_002434465.1 hemolysin III family protein -
FV156_RS06980 1440325..1440636 - 312 WP_165432307.1 N(4)-acetylcytidine aminohydrolase -
FV156_RS06985 1440749..1441486 + 738 WP_002434460.1 MurR/RpiR family transcriptional regulator -
FV156_RS06990 1441612..1443045 + 1434 WP_002434459.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16511.44 Da        Isoelectric Point: 10.5604

>T151383 WP_040459615.1 NZ_CP049608:c1437886-1437467 [Atlantibacter hermannii]
VVLWQSDLRVSWRAQWFSLMLHGIVAAIILLLPWPLSYMPLWLILLSLVVFDCVRSQRRIHSLQGEVKLTIDYRLRWQGI
EWELTAAPWMLQSGMLLRLRHPDTHRSQHLWLAADSMDAGEWRDLRRILMQQPQSGRHP

Download         Length: 420 bp

>T151383 NZ_CP065454:c158054-157704 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10549.05 Da        Isoelectric Point: 5.6178

>AT151383 WP_002434469.1 NZ_CP049608:c1438133-1437867 [Atlantibacter hermannii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRVFIRLLECDDPDLFNWLMNHGKPADSELQRMVQMIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT151383 NZ_CP065454:c157699-157397 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447LT15

Antitoxin

Source ID Structure
AlphaFold DB H5V069

References