Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3575461..3576115 Replicon chromosome
Accession NZ_CP049606
Organism Shigella boydii strain 600080

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag G5S61_RS18035 Protein ID WP_000244767.1
Coordinates 3575461..3575868 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag G5S61_RS18040 Protein ID WP_000354044.1
Coordinates 3575849..3576115 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S61_RS18015 (3571418) 3571418..3573151 - 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -
G5S61_RS18020 (3573157) 3573157..3573867 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G5S61_RS18025 (3573892) 3573892..3574788 - 897 WP_039066474.1 site-specific tyrosine recombinase XerD -
G5S61_RS18030 (3574900) 3574900..3575421 + 522 WP_001055867.1 flavodoxin FldB -
G5S61_RS18035 (3575461) 3575461..3575868 - 408 WP_000244767.1 protein YgfX Toxin
G5S61_RS18040 (3575849) 3575849..3576115 - 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
G5S61_RS18045 (3576358) 3576358..3577338 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
G5S61_RS18050 (3577534) 3577534..3578193 - 660 WP_039066478.1 hemolysin III family protein -
G5S61_RS18055 (3578363) 3578363..3578667 - 305 Protein_3568 N(4)-acetylcytidine aminohydrolase -
G5S61_RS18060 (3578712) 3578712..3580145 + 1434 WP_005076748.1 6-phospho-beta-glucosidase BglA -
G5S61_RS18065 (3580202) 3580202..3580945 - 744 WP_000951957.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T151380 WP_000244767.1 NZ_CP049606:c3575868-3575461 [Shigella boydii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T151380 NZ_CP049606:c3575868-3575461 [Shigella boydii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGTGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT151380 WP_000354044.1 NZ_CP049606:c3576115-3575849 [Shigella boydii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT151380 NZ_CP049606:c3576115-3575849 [Shigella boydii]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATAATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References