Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 964792..965410 Replicon chromosome
Accession NZ_CP049606
Organism Shigella boydii strain 600080

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G5S61_RS04670 Protein ID WP_001291435.1
Coordinates 964792..965010 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q0T7C3
Locus tag G5S61_RS04675 Protein ID WP_000344797.1
Coordinates 965036..965410 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S61_RS04630 (959907) 959907..960218 - 312 WP_000409911.1 MGMT family protein -
G5S61_RS04640 (960597) 960597..960950 + 354 WP_000878140.1 DUF1428 domain-containing protein -
G5S61_RS04645 (960992) 960992..961264 - 273 Protein_928 EAL domain-containing protein -
G5S61_RS04655 (962036) 962036..963319 - 1284 Protein_930 cyclic-guanylate-specific phosphodiesterase PdeB -
G5S61_RS04660 (963483) 963483..963953 - 471 WP_000136192.1 YlaC family protein -
G5S61_RS04665 (964069) 964069..964620 - 552 WP_000102569.1 maltose O-acetyltransferase -
G5S61_RS04670 (964792) 964792..965010 - 219 WP_001291435.1 HHA domain-containing protein Toxin
G5S61_RS04675 (965036) 965036..965410 - 375 WP_000344797.1 Hha toxicity modulator TomB Antitoxin
G5S61_RS04680 (965956) 965956..969105 - 3150 WP_001132471.1 efflux RND transporter permease AcrB -
G5S61_RS04685 (969128) 969128..970321 - 1194 WP_024260158.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T151361 WP_001291435.1 NZ_CP049606:c965010-964792 [Shigella boydii]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T151361 NZ_CP065447:2709630-2709848 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14513.38 Da        Isoelectric Point: 4.9091

>AT151361 WP_000344797.1 NZ_CP049606:c965410-965036 [Shigella boydii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQALQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT151361 NZ_CP065447:2709229-2709603 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TPD8

References