151359

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 925456..926300 Replicon chromosome
Accession NZ_CP049606
Organism Shigella boydii strain 600080

Toxin (Protein)


Gene name itaT Uniprot ID A0A4P7TPN5
Locus tag G5S61_RS04460 Protein ID WP_005060796.1
Coordinates 925456..925854 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A0A658YW11
Locus tag G5S61_RS04470 Protein ID WP_005072928.1
Coordinates 925989..926300 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S61_RS04445 (921191) 921191..922561 - 1371 WP_039065692.1 MFS transporter -
G5S61_RS04450 (922955) 922955..924454 + 1500 WP_178986806.1 tetratricopeptide repeat protein -
G5S61_RS04455 (924465) 924465..925400 + 936 WP_039065694.1 tetratricopeptide repeat protein -
G5S61_RS04460 (925456) 925456..925854 - 399 WP_005060796.1 GNAT family N-acetyltransferase Toxin
G5S61_RS04465 (925847) 925847..926005 - 159 WP_005053055.1 hypothetical protein -
G5S61_RS04470 (925989) 925989..926300 - 312 WP_005072928.1 DUF1778 domain-containing protein Antitoxin
G5S61_RS04475 (926485) 926485..927375 - 891 WP_000971346.1 heme o synthase -
G5S61_RS04480 (927387) 927387..927716 - 330 WP_039065695.1 cytochrome o ubiquinol oxidase subunit IV -
G5S61_RS04485 (927716) 927716..928330 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
G5S61_RS04490 (928320) 928320..930311 - 1992 Protein_898 cytochrome o ubiquinol oxidase subunit I -
G5S61_RS04495 (930333) 930333..930830 - 498 Protein_899 COX aromatic rich motif-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 916296..933482 17186


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(52-112)

Antitoxin

Vibrio phage ICP1, Orf50

(19-96)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14335.69 Da        Isoelectric Point: 9.1674

>T151359 WP_005060796.1 NZ_CP049606:c925854-925456 [Shigella boydii]
VRNSDCAAKALIDRQSGELIGICTFTAYSLERQRVSGVLQGSQPSEIGVVRLVMLGGARKYQKRGFGQDLLCDFFEHVKK
IHPALPIKGVYLDADPAAINFYARLGFVQLSATPNAFGAVPMFLAIQHILAA

Download         Length: 399 bp

>T151359 NZ_CP065447:677911-678013 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11410.11 Da        Isoelectric Point: 10.3388

>AT151359 WP_005072928.1 NZ_CP049606:c926300-925989 [Shigella boydii]
MLGKTAALYDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT151359 NZ_CP065447:c678020-677875 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TPN5

Antitoxin

Source ID Structure
AlphaFold DB A0A658YW11

References