Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 5321230..5321887 Replicon chromosome
Accession NZ_CP049604
Organism Klebsiella pneumoniae strain Kp8701

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag G7L41_RS26525 Protein ID WP_002916310.1
Coordinates 5321230..5321640 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag G7L41_RS26530 Protein ID WP_002916312.1
Coordinates 5321621..5321887 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7L41_RS26505 5317230..5318963 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
G7L41_RS26510 5318969..5319682 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G7L41_RS26515 5319705..5320601 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
G7L41_RS26520 5320702..5321223 + 522 WP_002916308.1 flavodoxin FldB -
G7L41_RS26525 5321230..5321640 - 411 WP_002916310.1 protein YgfX Toxin
G7L41_RS26530 5321621..5321887 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
G7L41_RS26535 5322133..5323116 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
G7L41_RS26540 5323267..5323926 - 660 WP_002916317.1 hemolysin III family protein -
G7L41_RS26545 5324090..5324401 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
G7L41_RS26550 5324451..5325179 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
G7L41_RS26555 5325298..5326731 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T151355 WP_002916310.1 NZ_CP049604:c5321640-5321230 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T151355 NZ_CP065444:5269913-5270296 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT151355 WP_002916312.1 NZ_CP049604:c5321887-5321621 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT151355 NZ_CP065444:5269671-5269913 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References