Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4483644..4484383 Replicon chromosome
Accession NZ_CP049600
Organism Klebsiella aerogenes strain 18-2341

Toxin (Protein)


Gene name tacT Uniprot ID A0A837K484
Locus tag G7033_RS21215 Protein ID WP_047048257.1
Coordinates 4483644..4484129 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag G7033_RS21220 Protein ID WP_015705366.1
Coordinates 4484117..4484383 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7033_RS21195 4479196..4480266 - 1071 WP_045394436.1 mannonate dehydratase -
G7033_RS21200 4480527..4480685 + 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
G7033_RS21205 4480740..4481840 - 1101 WP_047048252.1 NADH:flavin oxidoreductase/NADH oxidase -
G7033_RS21210 4481959..4483572 - 1614 WP_047048254.1 FAD-NAD(P)-binding protein -
G7033_RS21215 4483644..4484129 - 486 WP_047048257.1 GNAT family N-acetyltransferase Toxin
G7033_RS21220 4484117..4484383 - 267 WP_015705366.1 DUF1778 domain-containing protein Antitoxin
G7033_RS21225 4484656..4485891 + 1236 WP_047048260.1 MFS transporter -
G7033_RS21230 4485937..4486434 - 498 WP_047048263.1 heme-binding protein -
G7033_RS21235 4486530..4487147 - 618 WP_047048266.1 response regulator transcription factor -
G7033_RS21240 4487147..4488466 - 1320 WP_047048269.1 two-component sensor histidine kinase -
G7033_RS21245 4488463..4489050 - 588 WP_047048272.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17589.23 Da        Isoelectric Point: 8.8793

>T151330 WP_047048257.1 NZ_CP049600:c4484129-4483644 [Klebsiella aerogenes]
MGKVSAPTPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEDSHQVVGFYSLATGSVNHTEATGGLRRNM
PDPIPVIILARLAIDCAFHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T151330 NZ_CP065439:7916-8266 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT151330 WP_015705366.1 NZ_CP049600:c4484383-4484117 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT151330 NZ_CP065439:8271-8573 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837K484

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FSM9

References