Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3189387..3190006 Replicon chromosome
Accession NZ_CP049600
Organism Klebsiella aerogenes strain 18-2341

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag G7033_RS15045 Protein ID WP_015367918.1
Coordinates 3189387..3189605 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A837JZD4
Locus tag G7033_RS15050 Protein ID WP_045393536.1
Coordinates 3189632..3190006 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7033_RS15015 3185460..3185720 + 261 WP_015367923.1 type B 50S ribosomal protein L31 -
G7033_RS15020 3185723..3185863 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
G7033_RS15025 3185860..3186570 - 711 WP_045393548.1 GNAT family N-acetyltransferase -
G7033_RS15030 3186673..3188127 + 1455 WP_047047053.1 PLP-dependent aminotransferase family protein -
G7033_RS15035 3188102..3188566 - 465 WP_047047056.1 YlaC family protein -
G7033_RS15040 3188695..3189255 - 561 WP_047047059.1 maltose O-acetyltransferase -
G7033_RS15045 3189387..3189605 - 219 WP_015367918.1 hemolysin expression modulator Hha Toxin
G7033_RS15050 3189632..3190006 - 375 WP_045393536.1 Hha toxicity modulator TomB Antitoxin
G7033_RS15055 3190479..3193625 - 3147 WP_047047062.1 multidrug efflux RND transporter permease subunit AcrB -
G7033_RS15060 3193648..3194847 - 1200 WP_045393531.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T151329 WP_015367918.1 NZ_CP049600:c3189605-3189387 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T151329 NZ_CP065438:c5184559-5184074 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14492.26 Da        Isoelectric Point: 4.9045

>AT151329 WP_045393536.1 NZ_CP049600:c3190006-3189632 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPVSLSC

Download         Length: 375 bp

>AT151329 NZ_CP065438:c5184849-5184556 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A837JZD4

References