Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2442257..2442773 Replicon chromosome
Accession NZ_CP049600
Organism Klebsiella aerogenes strain 18-2341

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag G7033_RS11660 Protein ID WP_047046230.1
Coordinates 2442489..2442773 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag G7033_RS11655 Protein ID WP_047046232.1
Coordinates 2442257..2442499 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7033_RS11640 2438050..2438790 + 741 WP_045394691.1 KDGP aldolase family protein -
G7033_RS11645 2439095..2440246 + 1152 WP_045394693.1 lactonase family protein -
G7033_RS11650 2440269..2442179 + 1911 WP_047046234.1 BglG family transcription antiterminator -
G7033_RS11655 2442257..2442499 + 243 WP_047046232.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
G7033_RS11660 2442489..2442773 + 285 WP_047046230.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G7033_RS11665 2442777..2443241 - 465 WP_045386772.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
G7033_RS11670 2443775..2445913 - 2139 WP_032713553.1 anaerobic ribonucleoside-triphosphate reductase -
G7033_RS11675 2446270..2447013 - 744 WP_045394700.1 MurR/RpiR family transcriptional regulator -
G7033_RS11680 2447275..2447583 + 309 WP_020079792.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11054.91 Da        Isoelectric Point: 10.3787

>T151328 WP_047046230.1 NZ_CP049600:2442489-2442773 [Klebsiella aerogenes]
MTYELEFDPRALREWQKLGETVKKQFKNKLQQVVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T151328 NZ_CP065438:c5048991-5048584 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9013.49 Da        Isoelectric Point: 6.3340

>AT151328 WP_047046232.1 NZ_CP049600:2442257-2442499 [Klebsiella aerogenes]
MATLNVRLDDKLKKEAYAVLEKLDVTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT151328 NZ_CP065438:c5049238-5048972 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References