Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2063921..2064507 Replicon chromosome
Accession NZ_CP049600
Organism Klebsiella aerogenes strain 18-2341

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag G7033_RS09765 Protein ID WP_047047927.1
Coordinates 2064139..2064507 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag G7033_RS09760 Protein ID WP_004174006.1
Coordinates 2063921..2064142 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7033_RS09740 2060062..2060988 + 927 WP_047047924.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
G7033_RS09745 2060985..2062262 + 1278 WP_015369324.1 branched chain amino acid ABC transporter permease LivM -
G7033_RS09750 2062259..2063026 + 768 WP_015369325.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
G7033_RS09755 2063044..2063757 + 714 WP_086538103.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
G7033_RS09760 2063921..2064142 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G7033_RS09765 2064139..2064507 + 369 WP_047047927.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
G7033_RS09770 2064799..2066115 + 1317 WP_047047930.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
G7033_RS09775 2066222..2067109 + 888 WP_015369328.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
G7033_RS09780 2067106..2067951 + 846 WP_015369329.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
G7033_RS09785 2067953..2069023 + 1071 WP_047047932.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2060985..2069760 8775


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(26-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13697.09 Da        Isoelectric Point: 7.3194

>T151327 WP_047047927.1 NZ_CP049600:2064139-2064507 [Klebsiella aerogenes]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTEVWRLAVMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEATAGQLTLEQIVARLRE

Download         Length: 369 bp

>T151327 NZ_CP065438:c3915240-3915138 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT151327 WP_004174006.1 NZ_CP049600:2063921-2064142 [Klebsiella aerogenes]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT151327 NZ_CP065438:3915131-3915276 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References