Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2784803..2785387 Replicon chromosome
Accession NZ_CP049368
Organism Stenotrophomonas maltophilia strain MER1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag G6052_RS12895 Protein ID WP_165377533.1
Coordinates 2785205..2785387 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag G6052_RS12890 Protein ID WP_089236062.1
Coordinates 2784803..2785195 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6052_RS12865 2780376..2781461 - 1086 WP_165377528.1 3-phosphoserine/phosphohydroxythreonine transaminase -
G6052_RS12870 2781714..2782523 - 810 WP_165377529.1 FHA domain-containing protein -
G6052_RS12875 2782648..2782923 + 276 WP_165377530.1 polyhydroxyalkanoic acid system family protein -
G6052_RS12880 2783005..2783496 + 492 WP_165377531.1 phasin family protein -
G6052_RS12885 2783734..2784756 + 1023 WP_165377532.1 restriction endonuclease -
G6052_RS12890 2784803..2785195 - 393 WP_089236062.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
G6052_RS12895 2785205..2785387 - 183 WP_165377533.1 type II toxin-antitoxin system HicA family toxin Toxin
G6052_RS12900 2785474..2786202 - 729 WP_165377534.1 histidine utilization repressor -
G6052_RS12905 2786231..2787601 - 1371 WP_165377535.1 formimidoylglutamate deiminase -
G6052_RS12910 2787669..2788892 + 1224 WP_165377536.1 imidazolonepropionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6737.91 Da        Isoelectric Point: 11.1425

>T151324 WP_165377533.1 NZ_CP049368:c2785387-2785205 [Stenotrophomonas maltophilia]
MKSGDLIRELEAAGWSCRRIRGSHHVFVHPHRPHIITIPHPKKDLGKGLVQALRELAGLT

Download         Length: 183 bp

>T151324 NZ_CP065438:1122995-1123528 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13871.67 Da        Isoelectric Point: 4.1769

>AT151324 WP_089236062.1 NZ_CP049368:c2785195-2784803 [Stenotrophomonas maltophilia]
MRYPVLIEAGDERTAWSVIVPDLPGCFSAADTLDDALTSAEEAALGWIDAALDAGRPIPRPSSPQKIVAEADEATAWILA
YICVDPSLLDDTIERVNISLPRRILARLDAQAKAAGESRSSYIAHLAAQG

Download         Length: 393 bp

>AT151324 NZ_CP065438:1122718-1122984 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References