Detailed information of TA system TA151318

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2350088..2350725
• Replicon: chromosome
• Accession: NZ_CP049357
• Organism: Deinococcus wulumuqiensis R12

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6R31_RS11410
• Protein ID: WP_017871162.1
• Coordinates: 2350088..2350489 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6R31_RS11415
• Protein ID: WP_017871161.1
• Coordinates: 2350486..2350725 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6R31_RS11385	2345666..2346892	-	1227	WP_017871167.1	serine hydroxymethyltransferase	-
G6R31_RS11390	2347017..2347556	-	540	WP_017871166.1	hypothetical protein	-
G6R31_RS11395	2347759..2348337	-	579	WP_017871165.1	GTP cyclohydrolase I FolE	-
G6R31_RS11400	2348427..2349644	-	1218	WP_017871164.1	adenylosuccinate synthase	-
G6R31_RS11405	2349771..2350088	-	318	WP_017871163.1	DUF4180 domain-containing protein	-
G6R31_RS11410	2350088..2350489	-	402	WP_017871162.1	PIN domain-containing protein	Toxin
G6R31_RS11415	2350486..2350725	-	240	WP_017871161.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
G6R31_RS11420	2350836..2351918	-	1083	Protein_2239	transposase	-
G6R31_RS11425	2351908..2352321	-	414	WP_051056506.1	IS200/IS605 family transposase	-
G6R31_RS11430	2352539..2354098	-	1560	WP_017871158.1	2-oxo acid dehydrogenase subunit E2	-
G6R31_RS11435	2354095..2354343	-	249	WP_017871157.1	hypothetical protein	-
G6R31_RS11440	2354364..2355356	-	993	WP_017871156.1	alpha-ketoacid dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2345666..2352210	6544

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-126)

Antitoxin

• SpoVT-AbrB domain (7-42)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14603.87 Da
• Isoelectric Point: 7.4741

>T151318 WP_017871162.1 NZ_CP049357:c2350489-2350088 [Deinococcus wulumuqiensis R12]
VSLTHLLDTKTCIYIINRRPPHVAEKFAQHAPDAVGLSSITLAELRYGVAKSGSAKNAAVLEAFIQPLEIVPFDAEATRH
YGPLRHALQQQGRPIGAMGLLIAAHALALGVTLVTNNVKEFERVERLELENWF

Nucleotide

• Length: 402 bp

>T151318 NZ_CP065437:c115323-114907 [Klebsiella pneumoniae]
GTGAAAAAGACTTTTATGCTCGACACAAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCCCCGCGCCATATCGAGCTGGTTGACGCGTTCTGTGCCCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCCTTGCGACAGGCCGGGACGCCGATTGGTCCGAACGACACGGCGATAGC
CGGGCACGCCATCGCGGCCGGCGCCGTTCTGGTGACGAATAATGTAAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAATTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9104.32 Da
• Isoelectric Point: 5.0506

>AT151318 WP_017871161.1 NZ_CP049357:c2350725-2350486 [Deinococcus wulumuqiensis R12]
MTTAKLFQTGRSQAVRLPKAFRFEGQEVTIKRVSNGVLLIPNTAEGQQEFWRGWYAALPEVDIPLTREDLPLQERDWDS

Nucleotide

• Length: 240 bp

>AT151318 NZ_CP065437:c115550-115320 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGCGAGGATGTGGTCAGCGACGAAGGACGATTTGACCTGTGA