Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/VapC(toxin)
Location 1974939..1975504 Replicon chromosome
Accession NZ_CP049357
Organism Deinococcus wulumuqiensis R12

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6R31_RS09580 Protein ID WP_017870069.1
Coordinates 1974939..1975217 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6R31_RS09585 Protein ID WP_017870068.1
Coordinates 1975214..1975504 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6R31_RS09555 1970370..1970996 + 627 WP_017870074.1 single-stranded DNA-binding protein DdrA -
G6R31_RS09560 1970993..1971172 + 180 WP_017870073.1 hypothetical protein -
G6R31_RS09565 1971293..1972066 + 774 WP_017870072.1 methyltransferase domain-containing protein -
G6R31_RS09570 1972070..1972345 + 276 WP_040384208.1 hypothetical protein -
G6R31_RS09575 1972390..1974942 - 2553 WP_025567506.1 ATP-dependent helicase HrpB -
G6R31_RS09580 1974939..1975217 - 279 WP_017870069.1 hypothetical protein Toxin
G6R31_RS09585 1975214..1975504 - 291 WP_017870068.1 hypothetical protein Antitoxin
G6R31_RS09590 1975736..1977232 + 1497 WP_152423563.1 carboxylesterase/lipase family protein -
G6R31_RS09595 1977252..1977641 - 390 WP_017870066.1 DUF1232 domain-containing protein -
G6R31_RS09600 1977761..1978390 - 630 WP_017870065.1 HAD family hydrolase -
G6R31_RS09605 1978392..1978622 - 231 WP_040384200.1 hypothetical protein -
G6R31_RS09610 1978594..1979556 - 963 WP_017870063.1 NAD(P)/FAD-dependent oxidoreductase -
G6R31_RS09615 1979577..1980260 - 684 WP_017870062.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-152)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 9608.10 Da        Isoelectric Point: 5.4923

>T151317 WP_017870069.1 NZ_CP049357:c1975217-1974939 [Deinococcus wulumuqiensis R12]
MTPDSTALDANILSALLRSEANALPISRRLAALACEGSLIVSPVVHAELLAGPGVTPDFVIGAHALRRGDALFTADPQHD
RLGFPFLPVLTP

Download         Length: 279 bp

>T151317 NZ_CP065437:9682-10167 [Klebsiella pneumoniae]
GTGGGACGTGTAACAGTACCAGAACCTTTATCCAGCTTTCATCAGGTGGCGGAATTCGTTTGCGGTGAAACTGTTCTGGA
TGACTGGTTAAAGCAGAAAGGCCTCAAAAACCAGGCTCTCGGATCGGCCAGAACGTTTGTAGTGTGTAAAAAAGACACGA
AACAAGTAGCCGGTTTTTACTCTCTGGCCACCGGGAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCCGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCTTTCCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTCACCG
AAGAAGCTAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCAACGGACATTATTTCTTAAACTCCCT
CAATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10596.05 Da        Isoelectric Point: 5.6851

>AT151317 WP_017870068.1 NZ_CP049357:c1975504-1975214 [Deinococcus wulumuqiensis R12]
MTTHDARIENGKVVLIRIPLNSCTVGKAPPVHPYRGIRITPEQAADLGLREGEVLPVTAPPAEVQDNPFARWIGTLPPLP
DGEDSTQFYRRLRDGE

Download         Length: 291 bp

>AT151317 NZ_CP065437:9428-9694 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTTAATCTTAGAGCCAAGGAATCACAGCGGGCGCTCATTGACGCTGCTGCGGAAATTCTTCA
CAAATCACGAACAGACTTCATCCTGGAAATGGCCTGTCAGGCCGCTGAGAATGTGATCCTCGATCGCCGGGTCTTTAATT
TTAACGATGAACAATATGCCGAATTCATCGACATGCTTGATGCCCCTGTTGCAGATGATCCTGCCATAGATAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References