151303

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3981044..3981858 Replicon chromosome
Accession NZ_CP049353
Organism Escherichia coli strain T28R

Toxin (Protein)


Gene name yjhX Uniprot ID A0A6C9SL90
Locus tag G7B60_RS19220 Protein ID WP_001054375.1
Coordinates 3981044..3981301 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag G7B60_RS19225 Protein ID WP_001309181.1
Coordinates 3981313..3981858 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7B60_RS19200 3976332..3977438 + 1107 WP_001299704.1 N-acetylneuraminate epimerase -
G7B60_RS19205 3977503..3978483 + 981 WP_000991455.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
G7B60_RS19210 3979066..3980306 - 1241 Protein_3748 helicase YjhR -
G7B60_RS19215 3980422..3980667 + 246 Protein_3749 GNAT family N-acetyltransferase -
G7B60_RS19220 3981044..3981301 + 258 WP_001054375.1 hypothetical protein Toxin
G7B60_RS19225 3981313..3981858 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
G7B60_RS19230 3981914..3982660 + 747 WP_000354252.1 class I SAM-dependent methyltransferase -
G7B60_RS19235 3982829..3983047 + 219 Protein_3753 hypothetical protein -
G7B60_RS24570 3983085..3983201 + 117 Protein_3754 VOC family protein -
G7B60_RS19240 3983446..3984567 + 1122 WP_000010831.1 M42 family metallopeptidase -
G7B60_RS19245 3984564..3984842 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
G7B60_RS19250 3984854..3986167 + 1314 WP_000460845.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9768.31 Da        Isoelectric Point: 11.0090

>T151303 WP_001054375.1 NZ_CP049353:3981044-3981301 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QFDNR

Download         Length: 258 bp

>T151303 NZ_CP065432:449820-450209 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCAATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCACGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGTAGATTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19938.86 Da        Isoelectric Point: 6.3277

>AT151303 WP_001309181.1 NZ_CP049353:3981313-3981858 [Escherichia coli]
ITVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT151303 NZ_CP065432:449556-449813 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C9SL90

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References