Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2427739..2428377 Replicon chromosome
Accession NZ_CP049353
Organism Escherichia coli strain T28R

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag G7B60_RS11755 Protein ID WP_000813794.1
Coordinates 2428201..2428377 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag G7B60_RS11750 Protein ID WP_001270286.1
Coordinates 2427739..2428155 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7B60_RS11730 2422891..2423832 - 942 WP_001251313.1 ABC transporter permease -
G7B60_RS11735 2423833..2424846 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
G7B60_RS11740 2424864..2426009 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
G7B60_RS11745 2426254..2427660 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
G7B60_RS11750 2427739..2428155 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
G7B60_RS11755 2428201..2428377 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
G7B60_RS11760 2428599..2428829 + 231 WP_000494244.1 YncJ family protein -
G7B60_RS11765 2428921..2430882 - 1962 WP_001752477.1 23S rRNA 5-hydroxycytidine C2501 synthase -
G7B60_RS11770 2430955..2431491 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
G7B60_RS11775 2431544..2432773 + 1230 WP_071531711.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2432813..2433961 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T151299 WP_000813794.1 NZ_CP049353:c2428377-2428201 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T151299 NZ_CP065431:c1895286-1895029 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCCAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT151299 WP_001270286.1 NZ_CP049353:c2428155-2427739 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT151299 NZ_CP065431:c1895548-1895288 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References