151297

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2307055..2308643 Replicon chromosome
Accession NZ_CP049353
Organism Escherichia coli strain T28R

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag G7B60_RS11245 Protein ID WP_001125439.1
Coordinates 2307321..2308643 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag G7B60_RS11240 Protein ID WP_001301023.1
Coordinates 2307055..2307321 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7B60_RS11240 2307055..2307321 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
G7B60_RS11245 2307321..2308643 + 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
G7B60_RS11250 2308955..2309163 + 209 Protein_2196 helix-turn-helix transcriptional regulator -
G7B60_RS11255 2309418..2310644 + 1227 Protein_2197 fimbrial biogenesis outer membrane usher protein -
G7B60_RS11260 2310658..2311188 + 531 WP_000876763.1 type 1 fimbrial protein -
G7B60_RS11265 2311201..2311704 + 504 WP_000825452.1 type 1 fimbrial protein -
G7B60_RS11270 2311763..2312677 + 915 WP_000520676.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T151297 WP_001125439.1 NZ_CP049353:2307321-2308643 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T151297 NZ_CP065431:958570-959415 [Streptococcus suis]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGATTAACCTTTAATTCCGTGATGACCTA
TTACTTTTTAGAAATGATTTTGAAAAAATTAAGTCAGAGTGCCTACTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TGTCAAATGTTATTGGAGTTGAATCTCGTAGCACGGTTGATATTGATTTTTTGTTCCATCAAATGACACTCTCAGAAGAT
ACTGTGAAGCAGCAACTCAAGGAAATTTTAGTAGATTCAGAAGAAGGTATATCTTTTGTGATTCAATCAATCAAAGCTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTTGTGCCAACTTGAGAATATTAAACAAGTTATTCATTTGG
ATATTGCGACAGGCGATGTTGTAACTCCTCAGCCGATTACATACAACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACGATTGAAACAATTCTAGCTGAGAAACTTCAAACCATCTATTCACGCAACTTCTTGAACAGCAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAGAAAGAAGACATTGACTTCATTCAGTTGAGAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAACTCGATTTTGTAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGGGATTTCACTTGCAGATGTTCTTGATGA
GATGATTAGTCTTATTACAATTATTATTTCTACAGACTTAGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT151297 WP_001301023.1 NZ_CP049353:2307055-2307321 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp

>AT151297 NZ_CP065431:957983-958573 [Streptococcus suis]
ATGTCAAAAAAAGAGATTCTACTTGAATTTATAGAAAACCACAATGGTATTATCACCTATAGAGATTGTAAAGCTCTAAA
TATTCCAACAATATATTTGACAAGACTAGAAAAAGAAGGAATTCTATACCGCGTCGAAAAAGGAATTTTCCTAACCCAGA
ATGGAGACTACGACGAATACTACTTCTTTCAGTACCGATATCCCAAGGCTGTTTTCTCATATATCTCAGCGCTTTACCTG
CAACAATTTACAGATGAAATTCCTCAATATTTTGACGTAACCATTCCTAGAGGTTACCGTTTTAATACTCCTCCTGCTAA
CCTGAACATTCATTCCGTTTCTAAGGAATATAGCGAACTAGGAATTACTCTTGTAAAGACCCCTATGGGAAACGAAGTAA
GAGTGCATGATTTCGAACGTATTATCTGTGATTTTGTGATTCATCGAGAAAAAATAGATACTGAGCTTTTTGTCAAAACA
CTTCAACATTATGGAAACTATCCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAACACCTTGGACAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References