Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 1261935..1262560 | Replicon | chromosome |
| Accession | NZ_CP049353 | ||
| Organism | Escherichia coli strain T28R | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | G7B60_RS06060 | Protein ID | WP_000911330.1 |
| Coordinates | 1262162..1262560 (+) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | U9XQV3 |
| Locus tag | G7B60_RS06055 | Protein ID | WP_000450524.1 |
| Coordinates | 1261935..1262162 (+) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G7B60_RS06030 | 1257737..1258207 | - | 471 | WP_001068682.1 | thioredoxin-dependent thiol peroxidase | - |
| G7B60_RS06035 | 1258207..1258779 | - | 573 | WP_000176187.1 | glycine cleavage system transcriptional repressor | - |
| G7B60_RS06040 | 1258925..1259803 | + | 879 | WP_001311023.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| G7B60_RS06045 | 1259820..1260854 | + | 1035 | WP_001297320.1 | outer membrane protein assembly factor BamC | - |
| G7B60_RS06050 | 1261067..1261780 | + | 714 | WP_001295467.1 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | - |
| G7B60_RS06055 | 1261935..1262162 | + | 228 | WP_000450524.1 | toxin-antitoxin system antitoxin VapB | Antitoxin |
| G7B60_RS06060 | 1262162..1262560 | + | 399 | WP_000911330.1 | tRNA(fMet)-specific endonuclease VapC | Toxin |
| G7B60_RS06065 | 1262707..1263570 | + | 864 | WP_001267498.1 | neutral zinc metallopeptidase | - |
| G7B60_RS06070 | 1263585..1265600 | + | 2016 | WP_000829336.1 | tRNA cytosine(34) acetyltransferase TmcA | - |
| G7B60_RS06075 | 1265674..1266372 | + | 699 | WP_000679812.1 | esterase | - |
| G7B60_RS06080 | 1266482..1266682 | - | 201 | WP_000383836.1 | YpfN family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14894.25 Da Isoelectric Point: 9.2216
>T151287 WP_000911330.1 NZ_CP049353:1262162-1262560 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS
Download Length: 399 bp
>T151287 NZ_CP065430:285616-286413 [Streptococcus suis]
ATGAGATTGGAAGAATTTAGTGAGGCTGACTTTCAGAAGGCCTTACAGCGAACTATTAGGGCTCTAACTCGTGGAAAGAC
GATTCCAAATCAACCGAGAGCCATTTTGCTTGGAGGTCAGAGCGGAGCAGGTAAGACGACTATTCATCGAATTAAACAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACAAACTCAGCAC
GCAGGGTTATCACTTGCTGATTGAGGGAACCTTACGAACTACTCAAGTTCCTCGTCAGACTGCTCAATTATTATCTTCTA
AAGGTTACCAAGTTTCCTTAGCTGTAATTGGTACCAAACCAGAACTGTCCTATCTCAGTACCTTGATTCGTTACGAGGAA
CTTTATGCCGTAGATCCGACTCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTGGATAA
CCTAAGGCAGTTAGAAAGAGAGCAACTCTTTGACCAGATTCAAATTTATCATAGAGATAAAACTTGTATCTATGATTCTG
AAAGAGATGAAGGTTCCGCAGCAGAAGTGCTACAAGAATGCCTCTTTGGGCAATGGAGTAAGGTTGAGAAGGAGATGATG
AAGGTGGGGAAAGAGCGGTTGGATAAATTAAGTACCTTATCTAAAGAAAGCAATGGGAGAAATTACGACTTTATATGA
ATGAGATTGGAAGAATTTAGTGAGGCTGACTTTCAGAAGGCCTTACAGCGAACTATTAGGGCTCTAACTCGTGGAAAGAC
GATTCCAAATCAACCGAGAGCCATTTTGCTTGGAGGTCAGAGCGGAGCAGGTAAGACGACTATTCATCGAATTAAACAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACAAACTCAGCAC
GCAGGGTTATCACTTGCTGATTGAGGGAACCTTACGAACTACTCAAGTTCCTCGTCAGACTGCTCAATTATTATCTTCTA
AAGGTTACCAAGTTTCCTTAGCTGTAATTGGTACCAAACCAGAACTGTCCTATCTCAGTACCTTGATTCGTTACGAGGAA
CTTTATGCCGTAGATCCGACTCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTGGATAA
CCTAAGGCAGTTAGAAAGAGAGCAACTCTTTGACCAGATTCAAATTTATCATAGAGATAAAACTTGTATCTATGATTCTG
AAAGAGATGAAGGTTCCGCAGCAGAAGTGCTACAAGAATGCCTCTTTGGGCAATGGAGTAAGGTTGAGAAGGAGATGATG
AAGGTGGGGAAAGAGCGGTTGGATAAATTAAGTACCTTATCTAAAGAAAGCAATGGGAGAAATTACGACTTTATATGA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8498.61 Da Isoelectric Point: 4.3867
>AT151287 WP_000450524.1 NZ_CP049353:1261935-1262162 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF
Download Length: 228 bp
>AT151287 NZ_CP065430:285140-285616 [Streptococcus suis]
ATGATTGGAGACAATATCAAATCACTACGCCGAACACACGATTTAACACAACCAGAATTTGCGAAAATGGTTGGTATTTC
ACGCAATAGCCTGAGTCGCTACGAAAATGGAACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTCGGGGAGGATAAGATGTTAGCACCTGTTGAAGATTACCAACTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAAGATAGTCAAGACATCGCCTTTGATGATGA
ATCGAATCCGTGGGTTCTCATGAGTGATGACTTGGCCGAATTGATTAACACGAAAATTTACCTTGTCGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGACGGTATTGAGCGGATGTTAGACATGGTGCATCATCGGGTGATGGCTTAA
ATGATTGGAGACAATATCAAATCACTACGCCGAACACACGATTTAACACAACCAGAATTTGCGAAAATGGTTGGTATTTC
ACGCAATAGCCTGAGTCGCTACGAAAATGGAACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTCGGGGAGGATAAGATGTTAGCACCTGTTGAAGATTACCAACTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAAGATAGTCAAGACATCGCCTTTGATGATGA
ATCGAATCCGTGGGTTCTCATGAGTGATGACTTGGCCGAATTGATTAACACGAAAATTTACCTTGTCGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGACGGTATTGAGCGGATGTTAGACATGGTGCATCATCGGGTGATGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|