151285

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 809602..810256 Replicon chromosome
Accession NZ_CP049353
Organism Escherichia coli strain T28R

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag G7B60_RS03885 Protein ID WP_000244777.1
Coordinates 809849..810256 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag G7B60_RS03880 Protein ID WP_000354046.1
Coordinates 809602..809868 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7B60_RS03860 805571..807004 - 1434 WP_001753034.1 6-phospho-beta-glucosidase BglA -
G7B60_RS03865 807049..807360 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
G7B60_RS03870 807524..808183 + 660 WP_000250294.1 hemolysin III family protein -
G7B60_RS03875 808379..809359 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
G7B60_RS03880 809602..809868 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
G7B60_RS03885 809849..810256 + 408 WP_000244777.1 toxin CptA Toxin
G7B60_RS03890 810296..810817 - 522 WP_001055874.1 flavodoxin FldB -
G7B60_RS03895 810929..811825 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
G7B60_RS03900 811850..812560 + 711 WP_001753033.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G7B60_RS03905 812566..814299 + 1734 WP_000813188.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T151285 WP_000244777.1 NZ_CP049353:809849-810256 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T151285 NZ_CP065425:c3965470-3965120 [Bacillus vini]
TTGATTGTTAAGCGTGGTGACGTGTATTTTGCTGACCTTTCCCCTGTTGTCGGTTCCGAACAAGGCGGAGTCCGTCCTGT
TTTAGTCATCCAAAACGACATTGGGAATCGGTTTAGTCCCACTGTAATTGTTGCTGCTATTACAGCGCAAATCCAAAAGG
CAAAACTTCCTACACATGTTGAAATTGATGCAAAGCGTTATGGCTTTGAACGCGATTCTGTTATTTTGCTTGAACAAATT
CGCACAATTGATAAACAACGCTTAACAGACAAAATCACACATTTAGACGAAGAAATGATGGAAAAAGTGGACGATGCATT
ACAAATTAGTTTAGGACTTATAGAATTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT151285 WP_000354046.1 NZ_CP049353:809602-809868 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT151285 NZ_CP065425:c3965756-3965475 [Bacillus vini]
GTGTCTGAATCCAGCGCAACAACAGAAATATTAATTCGGTTACCGCAACAATTGTTAATAGAACTTGATGGATTTGCAGA
ACAAGAGAATATGAATCGTAATGAATTTATTTATCGCGCTACAAAAATGTATCTGCGTGAGCGTAAAAAAAGACAAATTC
GTGAATCAATGAGACGTGGCTACATGGAAATGGCTAAAATTAATTTAGCGATTGCATCTGAGGCGATTCAAGCAGAATAC
GAAGCAGAACATACAGTAGAACGCTTAGTAAGCGGGGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References