Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 166812..167347 | Replicon | plasmid p3R-1 |
| Accession | NZ_CP049349 | ||
| Organism | Escherichia coli strain 3R | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | V0VJJ7 |
| Locus tag | G6Q95_RS23950 | Protein ID | WP_000222760.1 |
| Coordinates | 166812..167099 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | V0VIP2 |
| Locus tag | G6Q95_RS23955 | Protein ID | WP_001132900.1 |
| Coordinates | 167096..167347 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G6Q95_RS23925 | 162395..163616 | - | 1222 | Protein_158 | ISL3 family transposase | - |
| G6Q95_RS23930 | 163716..164080 | + | 365 | Protein_159 | IS1 family transposase | - |
| G6Q95_RS23935 | 164135..164917 | - | 783 | WP_001442137.1 | IS21-like element IS100kyp family helper ATPase IstB | - |
| G6Q95_RS23940 | 164914..165936 | - | 1023 | WP_000255956.1 | IS21-like element IS100 family transposase | - |
| G6Q95_RS23945 | 166025..166372 | + | 348 | Protein_162 | IS1-like element IS1A family transposase | - |
| G6Q95_RS23950 | 166812..167099 | - | 288 | WP_000222760.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| G6Q95_RS23955 | 167096..167347 | - | 252 | WP_001132900.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| G6Q95_RS23965 | 168311..169168 | - | 858 | WP_000774297.1 | incFII family plasmid replication initiator RepA | - |
| G6Q95_RS23970 | 169161..169643 | - | 483 | WP_001273588.1 | hypothetical protein | - |
| G6Q95_RS23975 | 169636..169710 | - | 75 | WP_001442103.1 | RepA leader peptide Tap | - |
| G6Q95_RS23980 | 169942..170199 | - | 258 | WP_000083845.1 | replication regulatory protein RepA | - |
| G6Q95_RS23985 | 170483..170689 | - | 207 | WP_001351576.1 | type I toxin-antitoxin system Hok family toxin | - |
| - | 170676..170737 | + | 62 | NuclAT_1 | - | - |
| - | 170676..170737 | + | 62 | NuclAT_1 | - | - |
| - | 170676..170737 | + | 62 | NuclAT_1 | - | - |
| - | 170676..170737 | + | 62 | NuclAT_1 | - | - |
| G6Q95_RS25535 | 170993..171067 | - | 75 | Protein_170 | endonuclease | - |
| G6Q95_RS23990 | 171313..171525 | - | 213 | WP_001299730.1 | ANR family transcriptional regulator | - |
| G6Q95_RS23995 | 171661..172221 | - | 561 | WP_000139315.1 | fertility inhibition protein FinO | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sitABCD | iutA / iucD / iucC / iucB / iucA / iroB / iroC / iroD / iroE / iroN / vat | 1..194391 | 194391 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11105.15 Da Isoelectric Point: 10.5832
>T151265 WP_000222760.1 NZ_CP049349:c167099-166812 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKSIQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR
MTYTVKFRDDALKEWLKLDKSIQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR
Download Length: 288 bp
>T151265 NZ_CP065411:3942873-3943394 [Kosakonia radicincitans]
GTGGACAACCTGACCATCGAGATGTTCTCAGGAGAGACAGAGTATGAAACAGGAGGTTTTGATTGTGGTGAGGTATCGCT
CAACGCTTTTTTAACCAACCATCTCAAACGCCAGCATGATGGCAAAATTTTACGTGCCTGGCTCCTCGTAACGAAAACGC
CCAGGCCGCGCATTTTAGGCTATTACACCTTGTCTGGCGGCAGTTTCGAGAAAGAACAACTGCCCACGAAAACACAGCAA
AAAAAGGTGCCTTATCGCAATGTCCCTTGCGTCATATTAGGTCGGCTCGCTATTGATAAGTCACTCCAGGGAAACGGCTG
GGGAGAAATCCTGGTGGCTCATGCTATGAGGGTGGTTTACACCGCCTCACTTAACATCGGCGTACATGGGTTATTTGTCG
AAGCACTCACTGGCAACGCCAAAAAATTCTATGAAAAACTTGGCTTCATTCCGTTAGCCGATGGCAACCAGCATTCGCTG
TTCTATCCAACAAAGTCTATTGAACGACTGTTCGAAGAGTAA
GTGGACAACCTGACCATCGAGATGTTCTCAGGAGAGACAGAGTATGAAACAGGAGGTTTTGATTGTGGTGAGGTATCGCT
CAACGCTTTTTTAACCAACCATCTCAAACGCCAGCATGATGGCAAAATTTTACGTGCCTGGCTCCTCGTAACGAAAACGC
CCAGGCCGCGCATTTTAGGCTATTACACCTTGTCTGGCGGCAGTTTCGAGAAAGAACAACTGCCCACGAAAACACAGCAA
AAAAAGGTGCCTTATCGCAATGTCCCTTGCGTCATATTAGGTCGGCTCGCTATTGATAAGTCACTCCAGGGAAACGGCTG
GGGAGAAATCCTGGTGGCTCATGCTATGAGGGTGGTTTACACCGCCTCACTTAACATCGGCGTACATGGGTTATTTGTCG
AAGCACTCACTGGCAACGCCAAAAAATTCTATGAAAAACTTGGCTTCATTCCGTTAGCCGATGGCAACCAGCATTCGCTG
TTCTATCCAACAAAGTCTATTGAACGACTGTTCGAAGAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9211.41 Da Isoelectric Point: 4.0780
>AT151265 WP_001132900.1 NZ_CP049349:c167347-167096 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL
Download Length: 252 bp
>AT151265 NZ_CP065411:3942600-3942869 [Kosakonia radicincitans]
ATGCCCGCACTGAAAAAACAGCGCATAGATCTGCGACTAACGGATGAGGATAAGAAAATGATCGAAGAAGCGGCGGCAAT
GACCAATCAGACGGTCACACAATTTCTGGTTAACAGCGCTTCTGAACGTGCTGCGGAAGTGATTGAACAGCACCGTCGCC
TGATTCTCAGCGAGGAATCATGGAACCGGGTTATGGATGCTATCGAAAACCCACCAGCACCGAATGACAAACTTAAACGC
GCCGCAAAACGTCTGCAAAACATGGAGTGA
ATGCCCGCACTGAAAAAACAGCGCATAGATCTGCGACTAACGGATGAGGATAAGAAAATGATCGAAGAAGCGGCGGCAAT
GACCAATCAGACGGTCACACAATTTCTGGTTAACAGCGCTTCTGAACGTGCTGCGGAAGTGATTGAACAGCACCGTCGCC
TGATTCTCAGCGAGGAATCATGGAACCGGGTTATGGATGCTATCGAAAACCCACCAGCACCGAATGACAAACTTAAACGC
GCCGCAAAACGTCTGCAAAACATGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|