Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4741462..4742297 Replicon chromosome
Accession NZ_CP049348
Organism Escherichia coli strain 3R

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2S4A272
Locus tag G6Q95_RS22515 Protein ID WP_001094443.1
Coordinates 4741920..4742297 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag G6Q95_RS22510 Protein ID WP_001285607.1
Coordinates 4741462..4741830 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6Q95_RS22475 4737354..4738034 + 681 WP_001282919.1 WYL domain-containing protein -
G6Q95_RS22480 4738182..4738859 + 678 WP_001097301.1 hypothetical protein -
G6Q95_RS22485 4738865..4739098 + 234 WP_001278287.1 DUF905 family protein -
G6Q95_RS22490 4739188..4740006 + 819 WP_001175163.1 DUF945 domain-containing protein -
G6Q95_RS22495 4740098..4740583 + 486 WP_000206664.1 antirestriction protein -
G6Q95_RS22500 4740598..4741074 + 477 WP_001186165.1 RadC family protein -
G6Q95_RS22505 4741161..4741382 + 222 WP_000692350.1 DUF987 domain-containing protein -
G6Q95_RS22510 4741462..4741830 + 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
G6Q95_RS22515 4741920..4742297 + 378 WP_001094443.1 TA system toxin CbtA family protein Toxin
G6Q95_RS22520 4742294..4742782 + 489 WP_000761685.1 hypothetical protein -
G6Q95_RS22525 4742802..4742999 + 198 WP_001327226.1 DUF957 domain-containing protein -
G6Q95_RS22530 4743084..4743230 + 147 WP_001290178.1 hypothetical protein -
G6Q95_RS22540 4743692..4744957 + 1266 WP_001218329.1 integrase arm-type DNA-binding domain-containing protein -
G6Q95_RS22545 4745158..4746627 - 1470 WP_001022619.1 serine/threonine protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4715652..4746627 30975
- flank IS/Tn - - 4746914..4748122 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14058.97 Da        Isoelectric Point: 7.3523

>T151257 WP_001094443.1 NZ_CP049348:4741920-4742297 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T151257 NZ_CP065410:c2292938-2292654 [Pseudomonas sp. IAC-BECa141]
ATGCAGATTAAGTGGCGACCCAAGGCTCGGGTCGAACTCTCGAAAATACTGAAGTACATTGGCGAGCGAAATTTTGTAGC
GGCGACAGCACTTCACAAGTCAGTCGTAAAAACTACATCTGCGCTTCCTTGGCATCCACACCTGTATCGCAAAGGTCGCT
CTCCCGGCACTCGGGAGATTGTGGTAAGCCCGAACTATCTCGTCGTTTATCAAGTGGCGGACCGAATTGAGATTGTGAGC
ATCTTGCATGCGCGTCAGGAATACCCTCGACGCGACCCCAGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT151257 WP_001285607.1 NZ_CP049348:4741462-4741830 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT151257 NZ_CP065410:c2293134-2292928 [Pseudomonas sp. IAC-BECa141]
ATGATCGACCCGTCTTTGATCGACCCACTGTGCCCGGTTGTTTCGGATCTTGGTCCCGAGGAGCAGGCTGCGAGTTATGA
CCGTTGGTTTCGGGCCGAAGTACAGGCCTCTCTCGATGATCCGCGTCCGAGTATTCCCCATGAGCAAGTGATGGCGGAAA
TAAACGCCTTGATGGAATCAATGCGCAAAAGCGCTGATGCAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4A272

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References