Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4640320..4640915 Replicon chromosome
Accession NZ_CP049348
Organism Escherichia coli strain 3R

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag G6Q95_RS21965 Protein ID WP_000239579.1
Coordinates 4640565..4640915 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag G6Q95_RS21960 Protein ID WP_001223208.1
Coordinates 4640320..4640571 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6Q95_RS21950 4635985..4639764 + 3780 WP_064055548.1 autotransporter assembly complex protein TamB -
G6Q95_RS21955 4639767..4640108 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
G6Q95_RS21960 4640320..4640571 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
G6Q95_RS21965 4640565..4640915 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
G6Q95_RS21970 4640995..4641525 - 531 WP_000055075.1 inorganic diphosphatase -
G6Q95_RS21975 4641835..4642791 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
G6Q95_RS21980 4642931..4644433 + 1503 WP_000210554.1 sugar ABC transporter ATP-binding protein -
G6Q95_RS21985 4644447..4645469 + 1023 WP_001368084.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T151256 WP_000239579.1 NZ_CP049348:4640565-4640915 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T151256 NZ_CP065410:c303541-303227 [Pseudomonas sp. IAC-BECa141]
ATGATTTTTATTGAGACTCGGATCTTTACCCGTCGAGTAAAAGAGCTGCTGGACGATGACACTTACGCCGCTTTTCAGAA
GCAACTGGTTGTAAGTCCCTCGATTGGCGATGTAATTGAAGGCACAGGCGGGATCCGAAAAACCCGAATCGCAGCGAAAG
GACACGGCAAGCGAGGCGGAGCACGGGTTATCTACTACCACTTCGTTTCGGCATCACAAATCGGGTTATTGATGATCTAC
CCTAAAAATGAACAACACGATCTGTCCAGCGATGAGCGCAAAGCACTCAAGGTCTTGATCGAAAAATGGAGATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT151256 WP_001223208.1 NZ_CP049348:4640320-4640571 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT151256 NZ_CP065410:c303224-302937 [Pseudomonas sp. IAC-BECa141]
ATGAGCAAATTTTTTGATGAGCTGATGGAAAGTGTGCAAGAGATGGACGAGATCGTACGAGGCGAGCGCACACCTTCTCG
CGAATTCCACGTTGATGCTTTGCAGGTCAAAGAGATTCGTAAAGCTACCGGTTTGACCCAGGCCAAATTTGCGGCACTGA
TCGACGTCCAGCTCGGCACTCTACGAAATTGGGAACAGGGTCGTCGCGAGCCTACTGGGCCGGCAAAAGCTTTGCTCAAG
GCCATTCATAACGACCCGGTTCATGTTTTGAATGCATTGGCCCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References