Detailed information of TA system TA151253

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3995307..3996108
• Replicon: chromosome
• Accession: NZ_CP049348
• Organism: Escherichia coli strain 3R

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A0E0XS49
• Locus tag: G6Q95_RS18950
• Protein ID: WP_001094437.1
• Coordinates: 3995731..3996108 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A2S1XZS0
• Locus tag: G6Q95_RS18945
• Protein ID: WP_072645736.1
• Coordinates: 3995307..3995684 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6Q95_RS18910	3990546..3991250	+	705	WP_001067855.1	IS6-like element IS26 family transposase	-
G6Q95_RS18915	3991302..3992351	+	1050	Protein_3698	autotransporter domain-containing protein	-
G6Q95_RS18920	3992422..3992580	+	159	WP_001323397.1	DUF905 family protein	-
G6Q95_RS18925	3992735..3993553	+	819	WP_072645737.1	DUF945 domain-containing protein	-
G6Q95_RS18930	3993895..3994368	+	474	WP_000855064.1	antirestriction protein	-
G6Q95_RS18935	3994384..3994860	+	477	WP_001186775.1	RadC family protein	-
G6Q95_RS18940	3994923..3995144	+	222	WP_000692345.1	DUF987 domain-containing protein	-
G6Q95_RS18945	3995307..3995684	+	378	WP_072645736.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
G6Q95_RS18950	3995731..3996108	+	378	WP_001094437.1	TA system toxin CbtA family protein	Toxin
G6Q95_RS18955	3996105..3996593	+	489	WP_000761715.1	hypothetical protein	-
G6Q95_RS18960	3996613..3996810	+	198	WP_000772032.1	DUF957 domain-containing protein	-
G6Q95_RS18965	3996895..3997740	+	846	WP_001274561.1	DUF4942 domain-containing protein	-
G6Q95_RS18970	3997975..3998136	+	162	Protein_3709	virulence RhuM family protein	-
G6Q95_RS18975	3998533..3999717	+	1185	WP_001172876.1	sugar efflux transporter	-
G6Q95_RS18980	3999828..4000751	+	924	WP_000535960.1	carboxylate/amino acid/amine transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13986.90 Da
• Isoelectric Point: 7.3223

>T151253 WP_001094437.1 NZ_CP049348:3995731-3996108 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Nucleotide

• Length: 378 bp

>T151253 NZ_CP065407:c88174-87818 [Diaphorobacter sp. JS3051]
ATGCCTGATCACATCAAACAACTGCAGTGGGTTGGATCTGCGAAGAAGGATCTGCTAGCGATGCCCGAAGACGTCATTGA
CGTCTTTGGCTTCGCATTGCATCTCGCTCAGACAGGCAAGAAGCACGCGAATGCCAAGCCTTTGAGGGGTTTTGGCGGGG
CTGGCGTCCTCGAAGTGGTCGAGGATCACTTGGGCGACACCTATCGGGCTGTGTACACGGTGAAGATCGACGAGGCTGTC
TATGTGCTGCACTGTTTTCAGAAGAAGTCCAAGCAAGGCATCGAAACGCCAAAACATGACATGGACCTCATCCGAGAACG
CTTGAAGGCCGCACAAGCCGACGCCAAAGGAGCTTGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13787.61 Da
• Isoelectric Point: 5.9541

>AT151253 WP_072645736.1 NZ_CP049348:3995307-3995684 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAEPAITV

Nucleotide

• Length: 378 bp

>AT151253 NZ_CP065407:c87816-87496 [Diaphorobacter sp. JS3051]
ATGATTGAAATTGAGAAAGGTTCTGCCAACGTGTACGAAGACCTCGGGCTGCCCGACGCTTCCGAGATGTTGGTCAAAGC
CACCTTGGCCGCCAAGATCGGCGAGATCATCAAGCATCGTCACCTCACGCAGGTGCAGGCTTCGGAGATTCTCGGCATGC
CTCAACCCAAGCTGTCAGGGATGTTGCGCGGCCAGTTCCGTGGTATCAGTGAGGCCAAGATGCTCGAGTGCCTGAACCGC
TTGGGCCGGAACGTGGAAATCGTGGTTAGCAAGCCATCCCGCTCGGGCAGCGCAGGGCGAACCAGTGTGGTTTTCGCCTG
A

Structures

Toxin

• AlphaFold DB: A0A0E0XS49

Antitoxin

• AlphaFold DB: A0A2S1XZS0