Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3162562..3163394 Replicon chromosome
Accession NZ_CP049348
Organism Escherichia coli strain 3R

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag G6Q95_RS14915 Protein ID WP_000854753.1
Coordinates 3163020..3163394 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag G6Q95_RS14910 Protein ID WP_001278232.1
Coordinates 3162562..3162930 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6Q95_RS14880 3159398..3159853 + 456 WP_072645706.1 hypothetical protein -
G6Q95_RS14885 3159932..3160165 + 234 WP_001119729.1 DUF905 family protein -
G6Q95_RS14890 3160265..3161083 + 819 WP_001234620.1 DUF945 domain-containing protein -
G6Q95_RS14895 3161138..3161623 + 486 WP_000849582.1 antirestriction protein -
G6Q95_RS14900 3161639..3162115 + 477 WP_001186726.1 RadC family protein -
G6Q95_RS14905 3162178..3162399 + 222 WP_000692329.1 DUF987 domain-containing protein -
G6Q95_RS14910 3162562..3162930 + 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
G6Q95_RS14915 3163020..3163394 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
G6Q95_RS14920 3163391..3163879 + 489 WP_000777545.1 hypothetical protein -
G6Q95_RS14925 3163891..3164088 + 198 WP_000839281.1 DUF957 domain-containing protein -
G6Q95_RS14930 3164185..3164757 + 573 WP_001290246.1 DUF4942 domain-containing protein -
G6Q95_RS14935 3165038..3165574 - 537 WP_000942786.1 GspM family type II secretion system protein YghD -
G6Q95_RS14940 3165576..3166754 - 1179 WP_000094974.1 type II secretion system protein GspL -
G6Q95_RS14945 3166751..3167728 - 978 WP_000633222.1 type II secretion system minor pseudopilin GspK -
G6Q95_RS14950 3167731..3168330 - 600 WP_001255040.1 type II secretion system minor pseudopilin GspJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T151249 WP_000854753.1 NZ_CP049348:3163020-3163394 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T151249 NZ_CP065406:3949622-3950080 [Diaphorobacter sp. JS3051]
ATGCAACGGCATGGCTGGACGCTGCTCTTCCACGACTGCGTGATTGAGCCGTTGCAGAAACTGCAAGCGGCCGCGAGGCG
CGCGCAGGAGAACGACCCGAAAGGCTTCGAGTCCAATGCCAACGTCAAGCTGTTCCGGGCCTTGAGCCAGTTGATGTTGG
AAGTAGTGCCAGGCGATCCGGCACGCGACGAGTACCGTCAGGGCAATACCTTGGGATCGGCCCACCGCCACTGGCGAAGG
GCCAAAATCGGAAGGCGGTTCCGGCTGTTCTTCCGGTACGACTCGAAGGCGAAGGTCATCGTGTACGCCTGGGTCAACGA
TGAACAGACCCTGCGGTCTTCGGGTAGCAAGTCGGACCCGTATGTCGTCTTCGAGAAGATGCTCGGACGCGGGAACCCGC
CAGACGACTGGCACGCGCTGATACAGGCAAGCAAGCAGGATTGGAGCAAACTGGAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT151249 WP_001278232.1 NZ_CP049348:3162562-3162930 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT151249 NZ_CP065406:3949305-3949622 [Diaphorobacter sp. JS3051]
ATGCCTGCCATCCACGAAGTCGCCACGTTGACCTCCAAGGGCCAGGTCACGCTGCCCAAGCCTATCCGGCAGGCGCTGGG
CGTTGATGCCGGCGGCAAGCTCGCGTTCGATCTGCGGGGCAGCGAAGTCGTCGTCACCCGTGTCGATGCCGAGCACGAGG
ACCCCGCCATCGGCGCGTTCCTGAGCCTGCTGGCCCGCGACATCGAAGCTGGCCGGAACGTCCAGGGCCTGCCCGAGGAT
CTGGCCCGCGCCATGCTGGAGCATGCTGGCCATGGCGTGAACCTGGACGAGGAGATCGACGGGGAAGTGGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References