Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | itaRT/DUF1778(antitoxin) |
| Location | 490458..491295 | Replicon | chromosome |
| Accession | NZ_CP049348 | ||
| Organism | Escherichia coli strain 3R | ||
Toxin (Protein)
| Gene name | itaT | Uniprot ID | Q3Z4X7 |
| Locus tag | G6Q95_RS02255 | Protein ID | WP_000227784.1 |
| Coordinates | 490458..491000 (-) | Length | 181 a.a. |
Antitoxin (Protein)
| Gene name | itaR | Uniprot ID | I2UQS9 |
| Locus tag | G6Q95_RS02260 | Protein ID | WP_001297137.1 |
| Coordinates | 490984..491295 (-) | Length | 104 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G6Q95_RS02235 | 485997..486908 | - | 912 | WP_000705874.1 | 2-dehydropantoate 2-reductase | - |
| G6Q95_RS02240 | 487076..487567 | + | 492 | WP_001138904.1 | nucleotide binding protein YajQ | - |
| G6Q95_RS02245 | 487695..489059 | - | 1365 | WP_001000978.1 | MFS transporter | - |
| G6Q95_RS02250 | 489467..490402 | + | 936 | WP_001297127.1 | sel1 repeat family protein | - |
| G6Q95_RS02255 | 490458..491000 | - | 543 | WP_000227784.1 | GNAT family N-acetyltransferase | Toxin |
| G6Q95_RS02260 | 490984..491295 | - | 312 | WP_001297137.1 | DUF1778 domain-containing protein | Antitoxin |
| G6Q95_RS02265 | 491480..492370 | - | 891 | WP_000971332.1 | heme o synthase | - |
| G6Q95_RS02270 | 492382..492711 | - | 330 | WP_000019869.1 | cytochrome o ubiquinol oxidase subunit IV | - |
| G6Q95_RS02275 | 492711..493325 | - | 615 | WP_000179819.1 | cytochrome o ubiquinol oxidase subunit III | - |
| G6Q95_RS02280 | 493315..495306 | - | 1992 | WP_000467180.1 | cytochrome o ubiquinol oxidase subunit I | - |
| G6Q95_RS02285 | 495328..496275 | - | 948 | WP_001239441.1 | cytochrome o ubiquinol oxidase subunit II | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 181 a.a. Molecular weight: 19805.02 Da Isoelectric Point: 8.3395
>T151233 WP_000227784.1 NZ_CP049348:c491000-490458 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA
Download Length: 543 bp
>T151233 NZ_CP065401:1929463-1929565 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 104 a.a. Molecular weight: 11358.04 Da Isoelectric Point: 10.4825
>AT151233 WP_001297137.1 NZ_CP049348:c491295-490984 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA
Download Length: 312 bp
>AT151233 NZ_CP065401:c1929572-1929427 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|