Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4233043..4233540 Replicon chromosome
Accession NZ_CP049343
Organism Escherichia coli strain UMB200201_11

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag FM734_RS20140 Protein ID WP_001173343.1
Coordinates 4233043..4233216 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag FM734_RS20145 Protein ID WP_000398619.1
Coordinates 4233244..4233540 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FM734_RS20130 4229713..4231170 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
FM734_RS20135 4231407..4232924 + 1518 WP_001295074.1 lysine--tRNA ligase -
FM734_RS20140 4233043..4233216 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
FM734_RS20145 4233244..4233540 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
FM734_RS20150 4233767..4234039 - 273 WP_000405647.1 N-acetyltransferase -
FM734_RS20155 4234051..4234281 - 231 WP_000371698.1 (4Fe-4S)-binding protein -
FM734_RS20160 4234462..4236093 + 1632 WP_001216461.1 sensor histidine kinase -
FM734_RS20165 4236090..4236809 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T151230 WP_001173343.1 NZ_CP049343:c4233216-4233043 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T151230 NZ_CP065400:c1233271-1232852 [Brucella sp. BO2]
ATGATTGTCTTGGATACGAATGTCGTCTCCGAGGCGATGAAGCCCGAACCCAACCCGGCCGTGCGAGCTTGGTTGAATGA
GCAGGTAGCGGAAACCCTCTACCTGTCCAGCGTGACGCTGGCCGAACTGCTGTTCGGCATCGGCGCGCTACCGAACGGGA
AACGTAAGAAAGGCCTTGGCGAAGCCCTGGACGGCTTGCTCGAACTGTTCGGCGAGCGGGTGCTGATGTTCGACACCGAA
GCAGCTCGCCATTATGCCGAGCTGGCGGTGAAGGCCCGCACAGCCGGGAAGGGTTTTCCAACACCCGACGGATATATTGG
GGCTATTGCGGCCTCCAAGGGATTTATCGTAGCAACACGCGACACCAGCCCTTTCGAAGCGGCTGGGCTTACTGTTATCA
ATCCTTGGAACCATCAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT151230 WP_000398619.1 NZ_CP049343:c4233540-4233244 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT151230 NZ_CP065400:c1233522-1233268 [Brucella sp. BO2]
ATGGCAATCCTGACAGTGCGGAATGTGCCCGATGAGGTGCATCGCGCTCTGCGCTTACGGGCCGCCGAGCATGGCCGCAG
TACCGAGGCGGAGGTGCGCGAGATTCTGGAAAGTGCAGTGAAGTCGGAAGAGCGCATCCGCATGGGCGACGCTCTGGCGG
AGCTTGGCCGCCGCGTAGGGCTGACAAACGATGATTTTGCAGTGTTGGACCAGGTGCGCGACAAGGTGCCGGCAGAACCC
ATGAGGTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References